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GPCR

NameProteinase-activated receptor 4
SpeciesHomo sapiens (Human)
GeneF2RL3
Synonymprotease-activated receptor 4
PAR4
PAR-4
F2R like thrombin/trypsin receptor 3
coagulation factor II receptor-like 3
[ Show all ]
DiseaseN/A
Length385
Amino acid sequenceMWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAAADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASHWQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSPGDTVASKASAEGGSRGMGTHSSLLQ
UniProtQ96RI0
Protein Data BankN/A
GPCR-HGmod modelQ96RI0
3D structure modelThis predicted structure model is from GPCR-EXP Q96RI0.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4691
IUPHAR350
DrugBankN/A

Ligand

NameCHEMBL3718116
Molecular formulaC22H22N4O6S2
IUPAC name2-methoxy-6-[6-methoxy-4-[[2-(2-methoxyethoxymethyl)-1,3-thiazol-4-yl]methoxy]-1-benzofuran-2-yl]imidazo[2,1-b][1,3,4]thiadiazole
Molecular weight502.56
Hydrogen bond acceptor11
Hydrogen bond donor0
XlogP3.3
SynonymsCUQAZVNQNUWZDB-UHFFFAOYSA-N
SCHEMBL15348542
2-Methoxy-6-(6-methoxy-4-((2-((2-methoxyethoxy)methyl)thiazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
US9688695, 6
BDBM175973
Inchi KeyCUQAZVNQNUWZDB-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H22N4O6S2/c1-27-4-5-30-11-20-23-13(12-33-20)10-31-17-6-14(28-2)7-18-15(17)8-19(32-18)16-9-26-21(24-16)34-22(25-26)29-3/h6-9,12H,4-5,10-11H2,1-3H3
PubChem CID72193330
ChEMBLCHEMBL3718116
IUPHARN/A
BindingDB175973
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC500.68 nM, NoneBindingDB,ChEMBL
EC500.68 nMN/ABindingDB
EC502034.0 nMN/ABindingDB
IC502034.0 nMNoneChEMBL

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