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GPCR

NameG-protein coupled receptor 6
SpeciesHomo sapiens (Human)
GeneGPR6
SynonymGPR6
Sphingosine 1-phosphate receptor GPR6
DiseaseN/A
Length362
Amino acid sequenceMNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
UniProtP46095
Protein Data BankN/A
GPCR-HGmod modelP46095
3D structure modelThis predicted structure model is from GPCR-EXP P46095.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3714130
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3719318
Molecular formulaC24H28F4N6O4
IUPAC nameN-[(2S)-butan-2-yl]-3-[4-(2-fluoro-4-methoxyphenoxy)piperidin-1-yl]pyrazino[2,3-d]pyridazin-2-amine;2,2,2-trifluoroacetic acid
Molecular weight540.52
Hydrogen bond acceptor14
Hydrogen bond donor2
XlogPNone
SynonymsN/A
Inchi KeyCVNCIBFASUYCCO-UQKRIMTDSA-N
Inchi IDInChI=1S/C22H27FN6O2.C2HF3O2/c1-4-14(2)26-21-22(28-19-13-25-24-12-18(19)27-21)29-9-7-15(8-10-29)31-20-6-5-16(30-3)11-17(20)23;3-2(4,5)1(6)7/h5-6,11-15H,4,7-10H2,1-3H3,(H,26,27);(H,6,7)/t14-;/m0./s1
PubChem CID127024503
ChEMBLCHEMBL3719318
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
IC5021.0 nMNoneChEMBL

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