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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh1
Synonym	H1 receptor H1R HH1R Hisr
Disease	N/A for non-human GPCRs
Length	486
Amino acid sequence	MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
UniProt	P31390
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4701
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	LR 5182
Molecular formula	C17H24Cl3N
IUPAC name	[(2R,3S)-3-(3,4-dichlorophenyl)-2-bicyclo[2.2.2]octanyl]methyl-dimethylazanium;chloride
Molecular weight	348.736
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	None
Synonyms	62373-97-1 cis-3-(3,4-Dichlorophenyl)-N,N-dimethylbicyclo(2.2.2)octane-2-methanamine hydrochloride LS-43797 (-)-cis-2-(3,4-Dichlorophenyl)-3-dimethylaminomethylbicyclo(2.2.2)octane, hydrochloride Bicyclo(2.2.2)octane-2-methylamine, 3-(3,4-dichlorophenyl)-N,N-dimethyl-, hydrochloride, (Z)-(+)- [(2R,3S)-3-(3,4-dichlorophenyl)-2-bicyclo[2.2.2]octanyl]methyl-dimethylazanium chloride 62373-99-3 EW5182 AC1L2B00 LS-43798 (Z)-3-(3,4-Dichlorophenyl)-N,N-dimethylbicyclo(2.2.2)octane-2-methylamine hydrochloride Bicyclo(2.2.2)octane-2-methylamine, 3-(3,4-dichlorophenyl)-N,N-dimethyl-, hydrochloride, (Z)-(-)- 62374-00-9 (+)-cis-2-(3,4-Dichlorophenyl)-3-dimethylaminomethylbicyclo(2.2.2)octane, hydrochloride Bicyclo(2.2.2)octane-2-methylamine, 3-(3,4-dichlorophenyl)-N,N-dimethyl-, hydrochloride, (Z)- LS-43799 [ Show all ]
Inchi Key	CWRRQXXGIKGNJA-PQTJMFGHSA-N
Inchi ID	InChI=1S/C17H23Cl2N.ClH/c1-20(2)10-14-11-3-5-12(6-4-11)17(14)13-7-8-15(18)16(19)9-13;/h7-9,11-12,14,17H,3-6,10H2,1-2H3;1H/t11?,12?,14-,17-;/m1./s1
PubChem CID	44023
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82084
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2000.0 nM	PMID6123593	BindingDB

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