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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-X-C chemokine receptor type 5
Species	Homo sapiens (Human)
Gene	CXCR5
Synonym	BLR-1 NLR neurolymphatic receptor Monocyte-derived receptor 15 MDR15 MDR-15 Gpcr6 CXCR5 CXCR-5 CXC-R5 CD185 Burkitt lymphoma receptor 1 [ Show all ]
Disease	Systemic lupus erythematosus
Length	372
Amino acid sequence	MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
UniProt	P32302
Protein Data Bank	N/A
GPCR-HGmod model	P32302
3D structure model	This predicted structure model is from GPCR-EXP P32302.
BioLiP	N/A
Therapeutic Target Database	T09528
ChEMBL	CHEMBL1075315
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL3304406
Molecular formula	C22H20F3NO3
IUPAC name	2-[[2-(2-methylprop-1-enyl)-3-(trifluoromethyl)benzoyl]amino]-1,3-dihydroindene-2-carboxylic acid
Molecular weight	403.401
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	5.2
Synonyms	CHEMBL3717912 2-[2-(2-Methyl-propenyl)-3-trifluoromethyl-benzoylamino]-indan-2-carboxylic acid DYXHQOILPANHKB-UHFFFAOYSA-N
Inchi Key	DYXHQOILPANHKB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H20F3NO3/c1-13(2)10-17-16(8-5-9-18(17)22(23,24)25)19(27)26-21(20(28)29)11-14-6-3-4-7-15(14)12-21/h3-10H,11-12H2,1-2H3,(H,26,27)(H,28,29)
PubChem CID	68588620
ChEMBL	CHEMBL3717912
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	26.0 nM	None	ChEMBL

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