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GPCR

Name5-hydroxytryptamine receptor 2C
SpeciesRattus norvegicus (Rat)
GeneHtr2c
Synonym5-HT-1C
serotonin 1c receptor
HTR1C
5-hydroxytryptamine receptor 1C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
[ Show all ]
DiseaseN/A for non-human GPCRs
Length460
Amino acid sequenceMVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProtP08909
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL324
IUPHAR8
DrugBankBE0004882

Ligand

NameCHEMBL3819556
Molecular formulaC18H21ClFNS
IUPAC name2-[3-(4-fluorophenyl)sulfanylpropyl]-3,4-dihydro-1H-isoquinoline;hydrochloride
Molecular weight337.881
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogPNone
SynonymsSCHEMBL20359058
BDBM50182746
Inchi KeyFNLVWLRQYHPJGL-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H20FNS.ClH/c19-17-6-8-18(9-7-17)21-13-3-11-20-12-10-15-4-1-2-5-16(15)14-20;/h1-2,4-9H,3,10-14H2;1H
PubChem CID127052759
ChEMBLCHEMBL3819556
IUPHARN/A
BindingDB50182746
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki2623.0 nMPMID27312422BindingDB,ChEMBL
Ki2630.0 nMPMID27312422BindingDB
Ki2630.27 nMPMID27312422ChEMBL

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