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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesHomo sapiens (Human)
GeneHTR7
Synonym5-HT-7
Serotonin receptor 7
5-HT-X
5-HT1Y
5-HT7
[ Show all ]
DiseaseSleep disorders
Schizophrenia
Major depressive disorder
Length479
Amino acid sequenceMMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProtP34969
Protein Data BankN/A
GPCR-HGmod modelP34969
3D structure modelThis predicted structure model is from GPCR-EXP P34969.
BioLiPN/A
Therapeutic Target DatabaseT79062
ChEMBLCHEMBL3155
IUPHAR12
DrugBankBE0000650, BE0004862

Ligand

NameSB-258719
Molecular formulaC18H30N2O2S
IUPAC nameN,3-dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide
Molecular weight338.51
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP3.5
Synonyms4-Methyl-1-[(R)-3-methyl-4-(toluene-3-sulfonyl)-pentyl]-piperidine
D0H9QG
SB258719
195199-95-2
BDBM50098550
[ Show all ]
Inchi KeyAGVNHDNTFYHZNL-QGZVFWFLSA-N
Inchi IDInChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1
PubChem CID5312148
ChEMBLCHEMBL12264
IUPHAR281
BindingDB50098550
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki31.6 nMPMID9720804IUPHAR
Ki31.6 nMPMID23541835ChEMBL
Ki31.62 nMPMID10843226, PMID9720804, PMID9513592, PMID14667218BindingDB,ChEMBL
Ki32.0 nMPMID10843226, PMID23541835, PMID12161155, PMID12825922BindingDB,ChEMBL

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