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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesMus musculus (Mouse)
GenePtger3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3
prostanoid EP3 receptor
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWSDQLER
UniProtP30557
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4336
IUPHAR342
DrugBankN/A

Ligand

NameCHEMBL60555
Molecular formulaC19H32O5S
IUPAC name5-[[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]methylsulfanyl]pentanoic acid
Molecular weight372.52
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP2.2
Synonyms(11R,13E,15S)-9-Oxo-11,15-dihydroxy-6-thiaprosta-13-ene-1-oic acid
BDBM50101862
5-[(S)-(R)-3-Hydroxy-2-((1R,2R)-3-hydroxy-oct-1-enyl)-5-oxo-cyclopentylmethylsulfanyl]-pentanoic acid
Inchi KeyCWUOLAUUOCLFCW-ZVBMZXMJSA-N
Inchi IDInChI=1S/C19H32O5S/c1-2-3-4-7-14(20)9-10-15-16(18(22)12-17(15)21)13-25-11-6-5-8-19(23)24/h9-10,14-17,20-21H,2-8,11-13H2,1H3,(H,23,24)/b10-9+/t14-,15+,16+,17+/m0/s1
PubChem CID44304334
ChEMBLCHEMBL60555
IUPHARN/A
BindingDB50101862
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2.0 nMPMID11454474BindingDB,ChEMBL

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