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GPCR

NameProbable G-protein coupled receptor 34
SpeciesMus musculus (Mouse)
GeneGpr34
SynonymGPR34
DiseaseN/A for non-human GPCRs
Length375
Amino acid sequenceMTTTSVDSWLCSSHGMHFITNYSDQASQNFSGVPNVTSCPMDEKLLSTVLTTFYSVIFLVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAVADLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFISLDRYIKINRSIQQRRAITTKQSIYVCCIVWTVALAGFLTMIILTLKKGGHNSTMCFHYRDRHNAKGEAIFNFVLVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNSGKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIIHKTNEIMLVFSSFNSCLDPVMYFLMSSNIRKIMCQLLFRRFQSEASRSESTSEFKPGHSLHDLSVTVKMPQYSTKGN
UniProtQ9R1K6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075291
IUPHAR101
DrugBankN/A

Ligand

NameCHEMBL3814235
Molecular formulaC31H34NO11P
IUPAC name(2S)-2-amino-3-[hydroxy-[[(2R,3R)-2-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxymethyl]-3,6-dihydro-2H-pyran-3-yl]oxy]phosphoryl]oxypropanoic acid
Molecular weight627.583
Hydrogen bond acceptor12
Hydrogen bond donor3
XlogP0.3
SynonymsBDBM50177143
SCHEMBL15927992
Inchi KeyIANLQJOTLNXMJQ-WIIGKZCBSA-N
Inchi IDInChI=1S/C31H34NO11P/c32-26(31(34)35)20-41-44(36,37)43-28-14-7-17-38-29(28)21-40-30(33)16-15-23-9-4-5-13-27(23)39-19-22-8-6-12-25(18-22)42-24-10-2-1-3-11-24/h1-14,18,26,28-29H,15-17,19-21,32H2,(H,34,35)(H,36,37)/t26-,28+,29+/m0/s1
PubChem CID78319744
ChEMBLCHEMBL3814235
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50600.0 nMPMID27077565ChEMBL
EC50602.56 nMPMID27077565ChEMBL
Emax12.4 %PMID27077565ChEMBL
Intrinsic activity0.2 -PMID27077565ChEMBL

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