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GPCR

NamePutative P2Y purinoceptor 10
SpeciesMus musculus (Mouse)
GeneP2ry10
SynonymP2RY10
P2Y10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
DiseaseN/A for non-human GPCRs
Length328
Amino acid sequenceMGSNSTSSAESNCNATYLPFQYSLYATTYIFIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKYLNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAVIWIVVGTACLPFPILRNAGLANSTDSCFADLGYKQMDAVVLVTMVVIAELAGFVIPVITIACCTWKTTVSLKHPPIAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKESIITSCPTVKSTLYFHPFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVN
UniProtQ8BFU7
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562168
IUPHARN/A
DrugBankN/A

Ligand

NameCHEBI:52649
Molecular formulaC24H46NO9P
IUPAC name(2S)-2-amino-3-[hydroxy-[(2R)-2-hydroxy-3-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxypropanoic acid
Molecular weight523.604
Hydrogen bond acceptor10
Hydrogen bond donor4
XlogP2.1
Synonyms1-(9Z-octadecenoyl)-sn-glycero-3-phosphoserine
JZWNYZVVZXZRRH-YFKVPUFHSA-N
SCHEMBL15928095
1-oleoyl-sn-glycero-3-phosphoserine
LPS(18:1)
[ Show all ]
Inchi KeyJZWNYZVVZXZRRH-YFKVPUFHSA-N
Inchi IDInChI=1S/C24H46NO9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(27)32-18-21(26)19-33-35(30,31)34-20-22(25)24(28)29/h9-10,21-22,26H,2-8,11-20,25H2,1H3,(H,28,29)(H,30,31)/b10-9-/t21-,22+/m1/s1
PubChem CID9547099
ChEMBLCHEMBL1742484
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5024.55 nMPMID27077565ChEMBL
EC5025.0 nMPMID27077565ChEMBL
Emax12.5 %PMID27077565ChEMBL
Intrinsic activity0.073 -PMID27077565ChEMBL

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