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GPCR

NamePutative P2Y purinoceptor 10
SpeciesMus musculus (Mouse)
GeneP2ry10
SynonymP2RY10
P2Y10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
DiseaseN/A for non-human GPCRs
Length328
Amino acid sequenceMGSNSTSSAESNCNATYLPFQYSLYATTYIFIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKYLNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAVIWIVVGTACLPFPILRNAGLANSTDSCFADLGYKQMDAVVLVTMVVIAELAGFVIPVITIACCTWKTTVSLKHPPIAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKESIITSCPTVKSTLYFHPFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVN
UniProtQ8BFU7
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562168
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3815141
Molecular formulaC31H35ClNO11P
IUPAC name(2S)-2-amino-3-[[(2R,3R)-3-[3-[2-[[3-(4-chlorophenoxy)phenyl]methoxy]phenyl]propanoyloxy]oxan-2-yl]methoxy-hydroxyphosphoryl]oxypropanoic acid
Molecular weight664.041
Hydrogen bond acceptor12
Hydrogen bond donor3
XlogP1.3
SynonymsBDBM50177131
Inchi KeyLIMYTUSBKLMPQR-WIIGKZCBSA-N
Inchi IDInChI=1S/C31H35ClNO11P/c32-23-11-13-24(14-12-23)43-25-7-3-5-21(17-25)18-40-27-8-2-1-6-22(27)10-15-30(34)44-28-9-4-16-39-29(28)20-42-45(37,38)41-19-26(33)31(35)36/h1-3,5-8,11-14,17,26,28-29H,4,9-10,15-16,18-20,33H2,(H,35,36)(H,37,38)/t26-,28+,29+/m0/s1
PubChem CID127051444
ChEMBLCHEMBL3815141
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<1000.0 nMPMID27077565ChEMBL
EC50>1000.0 nMPMID27077565ChEMBL

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