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GPCR

NamePutative P2Y purinoceptor 10
SpeciesMus musculus (Mouse)
GeneP2ry10
SynonymP2RY10
P2Y10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
DiseaseN/A for non-human GPCRs
Length328
Amino acid sequenceMGSNSTSSAESNCNATYLPFQYSLYATTYIFIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKYLNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAVIWIVVGTACLPFPILRNAGLANSTDSCFADLGYKQMDAVVLVTMVVIAELAGFVIPVITIACCTWKTTVSLKHPPIAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKESIITSCPTVKSTLYFHPFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVN
UniProtQ8BFU7
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562168
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3814643
Molecular formulaC31H34NO11P
IUPAC name(2S)-2-amino-3-[hydroxy-[[(2R,3R)-3-[3-[2-[(3-phenoxyphenyl)methoxy]phenyl]propanoyloxy]-3,6-dihydro-2H-pyran-2-yl]methoxy]phosphoryl]oxypropanoic acid
Molecular weight627.583
Hydrogen bond acceptor12
Hydrogen bond donor3
XlogP0.3
SynonymsBDBM50177124
Inchi KeyQUMUJVAMABZIDA-WIIGKZCBSA-N
Inchi IDInChI=1S/C31H34NO11P/c32-26(31(34)35)20-40-44(36,37)41-21-29-28(14-7-17-38-29)43-30(33)16-15-23-9-4-5-13-27(23)39-19-22-8-6-12-25(18-22)42-24-10-2-1-3-11-24/h1-14,18,26,28-29H,15-17,19-21,32H2,(H,34,35)(H,36,37)/t26-,28+,29+/m0/s1
PubChem CID127048989
ChEMBLCHEMBL3814643
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50<1000.0 nMPMID27077565ChEMBL
EC50>1000.0 nMPMID27077565ChEMBL

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