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GPCR

NamefMet-Leu-Phe receptor
SpeciesHomo sapiens (Human)
GeneFPR1
SynonymNFPR
N-formylpeptide chemoattractant receptor
N-formyl peptide receptor
FPR1
FPR
[ Show all ]
DiseaseInflammatory disease
Peptic ulcer
Length350
Amino acid sequenceMETNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
UniProtP21462
Protein Data BankN/A
GPCR-HGmod modelP21462
3D structure modelThis predicted structure model is from GPCR-EXP P21462.
BioLiPN/A
Therapeutic Target DatabaseT87831
ChEMBLCHEMBL3359
IUPHAR222
DrugBankBE0000995

Ligand

NameSMR000025325
Molecular formulaC19H19N3O2S
IUPAC nameN-(2-ethoxyphenyl)-2-(1-phenylimidazol-2-yl)sulfanylacetamide
Molecular weight353.44
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.8
SynonymsN-(2-ethoxyphenyl)-2-(1-phenylimidazol-2-yl)sulfanyl-ethanamide
ZINC2723006
F0599-0049
N-(2-ethoxyphenyl)-2-[(1-phenyl-2-imidazolyl)thio]acetamide
AKOS024585909
[ Show all ]
Inchi KeyCXQUZZKPYSHPMV-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H19N3O2S/c1-2-24-17-11-7-6-10-16(17)21-18(23)14-25-19-20-12-13-22(19)15-8-4-3-5-9-15/h3-13H,2,14H2,1H3,(H,21,23)
PubChem CID3241796
ChEMBLCHEMBL1343699
IUPHARN/A
BindingDB37727
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<66700.0 nMN/ABindingDB
Ki<43700.0 nMN/ABindingDB
Ki<66700.0 nMPubChem BioAssay data setChEMBL

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