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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	C-X-C chemokine receptor type 5
Species	Homo sapiens (Human)
Gene	CXCR5
Synonym	BLR-1 NLR neurolymphatic receptor Monocyte-derived receptor 15 MDR15 MDR-15 Gpcr6 CXCR5 CXCR-5 CXC-R5 CD185 Burkitt lymphoma receptor 1 [ Show all ]
Disease	Systemic lupus erythematosus
Length	372
Amino acid sequence	MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
UniProt	P32302
Protein Data Bank	N/A
GPCR-HGmod model	P32302
3D structure model	This predicted structure model is from GPCR-EXP P32302.
BioLiP	N/A
Therapeutic Target Database	T09528
ChEMBL	CHEMBL1075315
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL3306006
Molecular formula	C19H19Cl2NO5S
IUPAC name	2-[(3,5-dichloro-2-propan-2-yloxyphenyl)sulfonylamino]-1,3-dihydroindene-2-carboxylic acid
Molecular weight	444.323
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.4
Synonyms	UDQBYOINRNOXIK-UHFFFAOYSA-N CHEMBL3717217 2-(3,5-Dichloro-2-isopropoxy-benzenesulfonylamino)-indan-2-carboxylic acid
Inchi Key	UDQBYOINRNOXIK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H19Cl2NO5S/c1-11(2)27-17-15(21)7-14(20)8-16(17)28(25,26)22-19(18(23)24)9-12-5-3-4-6-13(12)10-19/h3-8,11,22H,9-10H2,1-2H3,(H,23,24)
PubChem CID	25160278
ChEMBL	CHEMBL3717217
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	16000.0 nM	None	ChEMBL

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