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GPCR

NamePutative P2Y purinoceptor 10
SpeciesMus musculus (Mouse)
GeneP2ry10
SynonymP2RY10
P2Y10
purinergic receptor P2Y
purinergic receptor P2Y, G-protein coupled 10
purinergic receptor P2Y10
DiseaseN/A for non-human GPCRs
Length328
Amino acid sequenceMGSNSTSSAESNCNATYLPFQYSLYATTYIFIFIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHILSLPLRIYYYINRHWPFQRALCLLCFYLKYLNMYASIFFLTCISLQRCLFLLKPFRARNWKRRYDVGISAVIWIVVGTACLPFPILRNAGLANSTDSCFADLGYKQMDAVVLVTMVVIAELAGFVIPVITIACCTWKTTVSLKHPPIAFQGISERKKALRMVFMCAAVFVICFTPYHINFIFYTMVKESIITSCPTVKSTLYFHPFSLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSRESGSSMVN
UniProtQ8BFU7
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3562168
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3813751
Molecular formulaC29H46NO10P
IUPAC name(2S)-2-amino-3-[hydroxy-[[(2R,3R)-2-[3-(2-undecoxyphenyl)propanoyloxymethyl]-3,6-dihydro-2H-pyran-3-yl]oxy]phosphoryl]oxypropanoic acid
Molecular weight599.658
Hydrogen bond acceptor11
Hydrogen bond donor3
XlogP2.4
SynonymsBDBM50177142
SCHEMBL17309917
(2S)-2-Amino-3-[hydroxy[[(2R)-2alpha-[[3-[2-(undecyloxy)phenyl]propionyloxy]methyl]-3,6-dihydro-2H-pyran-3alpha-yl]oxy]phosphinyloxy]propionic acid
Inchi KeyZEVJFWDTRLIRIP-WYMJOSIYSA-N
Inchi IDInChI=1S/C29H46NO10P/c1-2-3-4-5-6-7-8-9-12-19-36-25-15-11-10-14-23(25)17-18-28(31)38-22-27-26(16-13-20-37-27)40-41(34,35)39-21-24(30)29(32)33/h10-11,13-16,24,26-27H,2-9,12,17-22,30H2,1H3,(H,32,33)(H,34,35)/t24-,26+,27+/m0/s1
PubChem CID78319710
ChEMBLCHEMBL3813751
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5041.69 nMPMID27077565ChEMBL
EC5042.0 nMPMID27077565ChEMBL
Emax12.4 %PMID27077565ChEMBL
Intrinsic activity0.05 -PMID27077565ChEMBL

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