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GPCR

NameC-X-C chemokine receptor type 5
SpeciesHomo sapiens (Human)
GeneCXCR5
SynonymBLR-1
NLR
neurolymphatic receptor
Monocyte-derived receptor 15
MDR15
[ Show all ]
DiseaseSystemic lupus erythematosus
Length372
Amino acid sequenceMNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF
UniProtP32302
Protein Data BankN/A
GPCR-HGmod modelP32302
3D structure modelThis predicted structure model is from GPCR-EXP P32302.
BioLiPN/A
Therapeutic Target DatabaseT09528
ChEMBLCHEMBL1075315
IUPHARN/A
DrugBankN/A

Ligand

NameSCHEMBL3308640
Molecular formulaC19H16FNO5
IUPAC name2-[(6-fluoro-4H-1,3-benzodioxine-8-carbonyl)amino]-1,3-dihydroindene-2-carboxylic acid
Molecular weight357.337
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.2
Synonyms2-[(6-Fluoro-4H-benzo[1,3]dioxine-8-carbonyl)-amino]-indan-2-carboxylic acid
ZJZLMAIBXQTSLO-UHFFFAOYSA-N
CHEMBL3715579
Inchi KeyZJZLMAIBXQTSLO-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H16FNO5/c20-14-5-13-9-25-10-26-16(13)15(6-14)17(22)21-19(18(23)24)7-11-3-1-2-4-12(11)8-19/h1-6H,7-10H2,(H,21,22)(H,23,24)
PubChem CID59314380
ChEMBLCHEMBL3715579
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5030000.0 nMNoneChEMBL

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