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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesHomo sapiens (Human)
GeneGPR119
SynonymGPCR2
GPR119
G-protein coupled receptor 2
G-protein coupled receptor 119
G protein-coupled receptor 119
[ Show all ]
DiseaseType 2 diabetes
Diabetes
Peripheral arterial disease; Type 2 diabetes
Non-insulin dependent diabetes
Gastric cancer; Type 2 diabetes
Length335
Amino acid sequenceMESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProtQ8TDV5
Protein Data BankN/A
GPCR-HGmod modelQ8TDV5
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDV5.
BioLiPN/A
Therapeutic Target DatabaseT93788
ChEMBLCHEMBL5652
IUPHAR126
DrugBankN/A

Ligand

NameSCHEMBL2586921
Molecular formulaC22H23N3O2
IUPAC name(4S,5S)-5-butyl-4-methyl-3-(2-phenyl-1,3-benzoxazol-6-yl)-4,5-dihydro-1H-pyridazin-6-one
Molecular weight361.445
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.0
SynonymsUS8772323, 197
CHEMBL3940831
BDBM180629
Inchi KeyACAFIORPGNSDEH-YOEHRIQHSA-N
Inchi IDInChI=1S/C22H23N3O2/c1-3-4-10-17-14(2)20(24-25-21(17)26)16-11-12-18-19(13-16)27-22(23-18)15-8-6-5-7-9-15/h5-9,11-14,17H,3-4,10H2,1-2H3,(H,25,26)/t14-,17-/m0/s1
PubChem CID67464400
ChEMBLCHEMBL3940831
IUPHARN/A
BindingDB180629
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501114.0 nM, NoneBindingDB,ChEMBL

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