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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3943310
Molecular formula	C23H30N4O3
IUPAC name	tert-butyl 4-[cyclopropyl-(4-pyrazol-1-ylbenzoyl)amino]piperidine-1-carboxylate
Molecular weight	410.518
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.3
Synonyms	BDBM254670 SCHEMBL15507101 US9469631, 71
Inchi Key	AGWBUDKPWBERJM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H30N4O3/c1-23(2,3)30-22(29)25-15-11-20(12-16-25)27(19-9-10-19)21(28)17-5-7-18(8-6-17)26-14-4-13-24-26/h4-8,13-14,19-20H,9-12,15-16H2,1-3H3
PubChem CID	89995530
ChEMBL	CHEMBL3943310
IUPHAR	N/A
BindingDB	254670
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	637.0 nM	, None	BindingDB,ChEMBL

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