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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesHomo sapiens (Human)
GenePTGER2
SynonymPGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
Ptger-ep2
[ Show all ]
DiseaseOsteoporosis
Pulmonary arterial hypertension
Miscarriage
Medical abortion
Immune disorder
[ Show all ]
Length358
Amino acid sequenceMGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProtP43116
Protein Data BankN/A
GPCR-HGmod modelP43116
3D structure modelThis predicted structure model is from GPCR-EXP P43116.
BioLiPN/A
Therapeutic Target DatabaseT38529
ChEMBLCHEMBL1881
IUPHAR341
DrugBankBE0000368

Ligand

NameCHEMBL354419
Molecular formulaC20H18N6O2
IUPAC name1-[3-[5-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]pyrimidin-7-yl]phenyl]piperidin-4-one
Molecular weight374.404
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP1.8
SynonymsN/A
Inchi KeyAHQGDBSNVPNSCB-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H18N6O2/c21-20-22-16(12-18-23-19(24-26(18)20)17-5-2-10-28-17)13-3-1-4-14(11-13)25-8-6-15(27)7-9-25/h1-5,10-12H,6-9H2,(H2,21,22)
PubChem CID23570252
ChEMBLN/A
IUPHARN/A
BindingDB50169546
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<10000.0 nMPMID26985320BindingDB
EC503.8 nMPMID26985320BindingDB

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