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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL3883407
Molecular formulaC28H27FO4
IUPAC name(3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
Molecular weight446.518
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP6.2
SynonymsSCHEMBL17391669
AKLYSRCTBBMCDZ-ZZHFZYNASA-N
(3S)-3-cyclopropyl-3-(2-(2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)chroman-7-yl)propanoic acid
BDBM50210155
Inchi KeyAKLYSRCTBBMCDZ-ZZHFZYNASA-N
Inchi IDInChI=1S/C28H27FO4/c1-32-22-11-12-25(29)24(15-22)18-4-6-19(7-5-18)26-13-10-20-8-9-21(14-27(20)33-26)23(16-28(30)31)17-2-3-17/h4-9,11-12,14-15,17,23,26H,2-3,10,13,16H2,1H3,(H,30,31)/t23-,26?/m0/s1
PubChem CID118623088
ChEMBLCHEMBL3883407
IUPHARN/A
BindingDB50210155
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity177.0 %PMID28197316ChEMBL
Activity277.0 %PMID28197316ChEMBL
Activity388.0 %PMID28197316ChEMBL
Activity447.0 %PMID28197316ChEMBL
EC5018.0 nMPMID28197316BindingDB,ChEMBL
EC5036.0 nMPMID28197316BindingDB,ChEMBL
EC501690.0 nMPMID28197316BindingDB,ChEMBL
EC505010.0 nMPMID28197316BindingDB,ChEMBL

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