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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL3909975
Molecular formula	C23H28IN3O4
IUPAC name	tert-butyl 4-[cyclopropyl-[4-(4-iodo-1,3-oxazol-5-yl)benzoyl]amino]piperidine-1-carboxylate
Molecular weight	537.398
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	4.1
Synonyms	BDBM254607 SCHEMBL15507366 4-{Cyclopropyl-[4-(4-iodo-oxazol-5-yl)-benzoyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester US9469631, 4 AWVYSKDKVYXUBZ-UHFFFAOYSA-N
Inchi Key	AWVYSKDKVYXUBZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H28IN3O4/c1-23(2,3)31-22(29)26-12-10-18(11-13-26)27(17-8-9-17)21(28)16-6-4-15(5-7-16)19-20(24)25-14-30-19/h4-7,14,17-18H,8-13H2,1-3H3
PubChem CID	73388223
ChEMBL	CHEMBL3909975
IUPHAR	N/A
BindingDB	254607
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
EC50	816.0 nM	, None	BindingDB,ChEMBL

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