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GPCR

NameVasopressin V1b receptor
SpeciesHomo sapiens (Human)
GeneAVPR1B
SynonymAVPR3
Vasopressin V3 receptor
vasopressin V1b receptor
V3/V1b pituitary vasopressin receptor
V3
[ Show all ]
DiseaseAnxiety disorder
Major depressive disorder; Anxiety
Major depressive disorder
Length424
Amino acid sequenceMDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLGRKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLELADGEGTAETIIF
UniProtP47901
Protein Data BankN/A
GPCR-HGmod modelP47901
3D structure modelThis predicted structure model is from GPCR-EXP P47901.
BioLiPN/A
Therapeutic Target DatabaseT59881
ChEMBLCHEMBL1921
IUPHAR367
DrugBankBE0000773

Ligand

NameSCHEMBL15988088
Molecular formulaC25H30ClFN6O3
IUPAC nameN-tert-butyl-2-[4-(3-chloro-4-fluorophenyl)-1-[5-(2-morpholin-4-ylethyl)pyridin-2-yl]-5-oxo-1,2,4-triazol-3-yl]acetamide
Molecular weight517.002
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP3.0
SynonymsUS9522914, D-32
BDBM260343
Inchi KeyAYDHJTKSXURNLQ-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H30ClFN6O3/c1-25(2,3)29-23(34)15-22-30-33(24(35)32(22)18-5-6-20(27)19(26)14-18)21-7-4-17(16-28-21)8-9-31-10-12-36-13-11-31/h4-7,14,16H,8-13,15H2,1-3H3,(H,29,34)
PubChem CID86581747
ChEMBLN/A
IUPHARN/A
BindingDB260343
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC5017.0 nMN/ABindingDB

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