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GPCR

NameVasoactive intestinal polypeptide receptor 2
SpeciesHomo sapiens (Human)
GeneVIPR2
SynonymVPAC2
VIP-R-2
VIP and PACAP receptor 2
PVR3
Pituitary adenylate cyclase-activating polypeptide type III receptor
[ Show all ]
DiseaseUnspecified
Chronic obstructive pulmonary disease
Hypertension
Length438
Amino acid sequenceMRTLLPPALLTCWLLAPVNSIHPECRFHLEIQEEETKCAELLRSQTEKHKACSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDGWSETFPDFVDACGYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAISVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRRCFLAYLLIGWGLPTVCIGAWTAARLYLEDTGCWDTNDHSVPWWVIRIPILISIIVNFVLFISIIRILLQKLTSPDVGGNDQSQYKRLAKSTLLLIPLFGVHYMVFAVFPISISSKYQILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRCPTPSASRDYRVCGSSFSRNGSEGALQFHRGSRAQSFLQTETSVI
UniProtP41587
Protein Data BankN/A
GPCR-HGmod modelP41587
3D structure modelThis predicted structure model is from GPCR-EXP P41587.
BioLiPN/A
Therapeutic Target DatabaseT06182
ChEMBLCHEMBL4532
IUPHAR372
DrugBankN/A

Ligand

NameCHEMBL3898495
Molecular formulaC31H39N3O5S
IUPAC name(2R,4S)-2-benzyl-4-hydroxy-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5-[[4-(2-methylpropylamino)phenyl]sulfonylamino]pentanamide
Molecular weight565.729
Hydrogen bond acceptor7
Hydrogen bond donor5
XlogP4.1
SynonymsSCHEMBL17038243
Inchi KeyDGOQFXJBMQXIPB-YSSKZCQZSA-N
Inchi IDInChI=1S/C31H39N3O5S/c1-21(2)19-32-25-12-14-27(15-13-25)40(38,39)33-20-26(35)17-24(16-22-8-4-3-5-9-22)31(37)34-30-28-11-7-6-10-23(28)18-29(30)36/h3-15,21,24,26,29-30,32-33,35-36H,16-20H2,1-2H3,(H,34,37)/t24-,26+,29-,30+/m1/s1
PubChem CID118334891
ChEMBLCHEMBL3898495
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition5.2 %NoneChEMBL
Inhibition10.2 %NoneChEMBL
Inhibition11.9 %NoneChEMBL
Inhibition16.7 %NoneChEMBL
Inhibition21.6 %NoneChEMBL
Inhibition27.4 %NoneChEMBL

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