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GPCR

NameCannabinoid receptor 2
SpeciesMus musculus (Mouse)
GeneCnr2
SynonymPeripheral cannabinoid receptor
mCB2
CB2-R
CB2 receptor
CB2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length347
Amino acid sequenceMEGCRETEVTNGSNGGLEFNPMKEYMILSSGQQIAVAVLCTLMGLLSALENMAVLYIILSSRRLRRKPSYLFISSLAGADFLASVIFACNFVIFHVFHGVDSNAIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALCVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHRHVATLAEHQDRQVPGIARMRLDVRLAKTLGLVLAVLLICWFPALALMGHSLVTTLSDQVKEAFAFCSMLCLVNSMVNPIIYALRSGEIRSAAQHCLIGWKKYLQGLGPEGKEEGPRSSVTETEADVKTT
UniProtP47936
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5373
IUPHAR57
DrugBankN/A

Ligand

NameDronabinol
Molecular formulaC21H30O2
IUPAC name(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol
Molecular weight314.469
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP7.0
SynonymsDSSTox_CID_1327
HSDB 6471
L-trans-delta9-Tetrahydrocannabinol
PDSP2_000714
Tetrahydro-6,6,9-trimethyl-3-pentyl-6H-di benzo[b,d]pyran-1-ol
[ Show all ]
Inchi KeyCYQFCXCEBYINGO-IAGOWNOFSA-N
Inchi IDInChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1
PubChem CID16078
ChEMBLCHEMBL465
IUPHAR2424
BindingDB60994
DrugBankDB00470

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki9.2 nMPMID17531479BindingDB,ChEMBL
Ki39.0 nMPMID8809166BindingDB
Ki39.3 nMPMID8809166ChEMBL
Ki40.0 nMPMID24900848BindingDB,ChEMBL

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