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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL365055
Molecular formula	C22H27F3N4O4
IUPAC name	N-[2-(diethylamino)ethyl]-2-methoxy-4-[[4-(trifluoromethoxy)phenyl]carbamoylamino]benzamide
Molecular weight	468.477
Hydrogen bond acceptor	8
Hydrogen bond donor	3
XlogP	3.8
Synonyms	SCHEMBL6108985 BDBM50153209 N-(2-Diethylamino-ethyl)-2-methoxy-4-[3-(4-trifluoromethoxy-phenyl)-ureido]-benzamide
Inchi Key	CYQHDGVGYUKXFU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27F3N4O4/c1-4-29(5-2)13-12-26-20(30)18-11-8-16(14-19(18)32-3)28-21(31)27-15-6-9-17(10-7-15)33-22(23,24)25/h6-11,14H,4-5,12-13H2,1-3H3,(H,26,30)(H2,27,28,31)
PubChem CID	10434776
ChEMBL	CHEMBL365055
IUPHAR	N/A
BindingDB	50153209
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	50.0 nM	PMID15380202	BindingDB,ChEMBL
IC50	150.0 nM	PMID15380202	BindingDB,ChEMBL
IC50	260.0 nM	PMID15380202	BindingDB,ChEMBL

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