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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	Renzapride
Molecular formula	C16H22ClN3O2
IUPAC name	4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide
Molecular weight	323.821
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.1
Synonyms	CAS_109872-41-5 4-Amino-5-chloro-2-methoxy-N-[1-azabicyclo[3.3.1]nonan-4-yl]benzamide endo-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3,3,1]non-4-yl)benzamide AC1MHYZY D04BOT 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide L000945 BDBM82422 SCHEMBL4534994 D06396 NSC_3035240 [ Show all ]
Inchi Key	GZSKEXSLDPEFPT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-14-4-6-20-5-2-3-10(14)9-20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)
PubChem CID	3035241
ChEMBL	N/A
IUPHAR	N/A
BindingDB	82422
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	173.0 nM	PMID9603189	BindingDB
Ki	173.78 nM	PMID9351641	BindingDB
Ki	199.5 nM	PMID11218067	BindingDB
Ki	251.18 nM	PMID8867105	BindingDB
Ki	251.2 nM	PMID11218067	BindingDB
Ki	635.0 nM	PMID9603189	BindingDB
Ki	636.0 nM	PMID9603189	BindingDB
Ki	1179.0 nM	PMID9603189	BindingDB

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