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Name | C-X-C chemokine receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | CXCR1 |
Synonym | CDw128a IL8RA IL-8R A IL-8 receptor type I IL-8 receptor type 1 [ Show all ] |
Disease | N/A |
Length | 350 |
Amino acid sequence | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL |
UniProt | P25024 |
Protein Data Bank | N/A |
GPCR-HGmod model | P25024 |
3D structure model | This predicted structure model is from GPCR-EXP P25024. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4029 |
IUPHAR | 68 |
DrugBank | BE0003552 |
Name | CHEMBL3915853 |
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Molecular formula | C24H27N3O5S |
IUPAC name | 2-hydroxy-N,N-dimethyl-3-[[2-[[(5-methylfuran-2-yl)-(thian-4-yl)methyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide |
Molecular weight | 469.556 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 3 |
XlogP | 3.6 |
Synonyms | SCHEMBL14895104 |
Inchi Key | IBEUBSDJSIGMBZ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C24H27N3O5S/c1-13-7-8-17(32-13)18(14-9-11-33-12-10-14)26-20-19(22(29)23(20)30)25-16-6-4-5-15(21(16)28)24(31)27(2)3/h4-8,14,18,25-26,28H,9-12H2,1-3H3 |
PubChem CID | 71550940 |
ChEMBL | CHEMBL3915853 |
IUPHAR | N/A |
BindingDB | 177693 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 3391.0 nM | , None | BindingDB,ChEMBL |
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