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GLASS

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GPCR

Name	Taste receptor type 2 member 14
Species	Homo sapiens (Human)
Gene	TAS2R14
Synonym	T2R14 TAS2R14 Taste receptor family B member 1 taste receptor, type 2, member 14 TRB1
Disease	N/A
Length	317
Amino acid sequence	MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
UniProt	Q9NYV8
Protein Data Bank	N/A
GPCR-HGmod model	Q9NYV8
3D structure model	This predicted structure model is from GPCR-EXP Q9NYV8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3309105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SCHEMBL1279010
Molecular formula	C25H25NO5S
IUPAC name	4-[(4-methoxyphenyl)methyl-(1,2,3,4-tetrahydronaphthalen-1-yl)sulfamoyl]benzoic acid
Molecular weight	451.537
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	4.3
Synonyms	US9247759, 5-150 CHEMBL3916083 US9247759, 5-96 BDBM211156
Inchi Key	JTTXZORULVWRFT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H25NO5S/c1-31-21-13-9-18(10-14-21)17-26(24-8-4-6-19-5-2-3-7-23(19)24)32(29,30)22-15-11-20(12-16-22)25(27)28/h2-3,5,7,9-16,24H,4,6,8,17H2,1H3,(H,27,28)
PubChem CID	57422387
ChEMBL	CHEMBL3916083
IUPHAR	N/A
BindingDB	211156
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2415.0 nM	None	ChEMBL
IC50	2415.0 nM	N/A	BindingDB

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