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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 142
Species	Mus musculus (Mouse)
Gene	Gpr142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A for non-human GPCRs
Length	365
Amino acid sequence	MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
UniProt	Q7TQN9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069162
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2017410
Molecular formula	C25H22N6O2
IUPAC name	2-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-N-naphthalen-1-ylacetamide
Molecular weight	438.491
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.7
Synonyms	BDBM50381477 SCHEMBL3049807
Inchi Key	MYWAKYXOZTWEIR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H22N6O2/c1-17-13-30(16-26-17)23-11-10-19(12-24(23)33-2)22-14-31(29-28-22)15-25(32)27-21-9-5-7-18-6-3-4-8-20(18)21/h3-14,16H,15H2,1-2H3,(H,27,32)
PubChem CID	59472644
ChEMBL	CHEMBL2017410
IUPHAR	N/A
BindingDB	50381477
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	23.0 nM	PMID27994747	BindingDB,ChEMBL
EC50	37.0 nM	PMID27994747	BindingDB,ChEMBL

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