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Name | 5-hydroxytryptamine receptor 2B |
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Species | Mus musculus (Mouse) |
Gene | Htr2b |
Synonym | 5-HT-2B serotonin receptor 2B NP75 protein 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 5-HT2F [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 479 |
Amino acid sequence | MASSYKMSEQSTTSEHILQKTCDHLILTNRSGLETDSVAEEMKQTVEGQGHTVHWAALLILAVIIPTIGGNILVILAVALEKRLQYATNYFLMSLAIADLLVGLFVMPIALLTIMFEAIWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRATAFIKITVVWLISIGIAIPVPIKGIETDVINPHNVTCELTKDRFGSFMVFGSLAAFFAPLTIMVVTYFLTIHTLQKKAYLVKNKPPQRLTRWTVPTVFLREDSSFSSPEKVAMLDGSHRDKILPNSSDETLMRRMSSVGKRSAQTISNEQRASKALGVVFFLFLLMWCPFFITNLTLALCDSCNQTTLKTLLEIFVWIGYVSSGVNPLIYTLFNKTFREAFGRYITCNYRATKSVKALRKFSSTLCFGNSMVENSKFFTKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSYI |
UniProt | Q02152 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2583 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL3946540 |
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Molecular formula | C21H25ClN2O2 |
IUPAC name | (2S)-2-[(3-chlorophenoxy)methyl]-4-[2-(2,3-dihydroindol-1-yl)ethyl]morpholine |
Molecular weight | 372.893 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 4.1 |
Synonyms | SCHEMBL14060270 US9079895, 23s BDBM186935 QAJBOIGVHPCSNX-FQEVSTJZSA-N (S)-2-((3-chlorophenoxy)methyl)-4-(2-(indolin-1-yl)ethyl)morpholine |
Inchi Key | QAJBOIGVHPCSNX-FQEVSTJZSA-N |
Inchi ID | InChI=1S/C21H25ClN2O2/c22-18-5-3-6-19(14-18)26-16-20-15-23(12-13-25-20)10-11-24-9-8-17-4-1-2-7-21(17)24/h1-7,14,20H,8-13,15-16H2/t20-/m0/s1 |
PubChem CID | 71061709 |
ChEMBL | CHEMBL3946540 |
IUPHAR | N/A |
BindingDB | 186935 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 551.0 nM | , None | BindingDB,ChEMBL |
Ki | 1846.0 nM | None | ChEMBL |
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