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GPCR

Name	P2Y purinoceptor 2
Species	Homo sapiens (Human)
Gene	P2RY2
Synonym	Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 P2Y ATP receptor 2 P2U1 P2U receptor 1 P2U purinoceptor 1 ATP receptor [ Show all ]
Disease	Dry eye disease Constipation Cystic fibrosis Lung cancer
Length	377
Amino acid sequence	MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProt	P41231
Protein Data Bank	N/A
GPCR-HGmod model	P41231
3D structure model	This predicted structure model is from GPCR-EXP P41231.
BioLiP	N/A
Therapeutic Target Database	T93515
ChEMBL	CHEMBL4398
IUPHAR	324
DrugBank	BE0002401

Ligand

Name	dUTP
Molecular formula	C9H15N2O14P3
IUPAC name	[[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular weight	468.14
Hydrogen bond acceptor	14
Hydrogen bond donor	6
XlogP	-5.5
Synonyms	DB02333 N(4)-Methoxydeoxycytidine triphosphate Uridine, 2'-deoxy-, 5'-triphosphate (7CI) 2'-Deoxyuracil 5'-triphosphate 2'-Deoxyuridine-5'-triphosphoric acid AHCYMLUZIRLXAA-SHYZEUOFSA-N C00460 Deoxyuridine triphosphate Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy- (9CI) [[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate ({[({[(2R,3S,5R)-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid 2'-deoxyuridine triphosphate 2-Deoxyuridine-5-triphosphoric acid= dutp CHEMBL374361 Uridine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate) (8CI) 2''-deoxyuridine 5''-(tetrahydrogen triphosphate) 2'-Deoxyuridine-5'-triphosphate, 100MM Solution 84772-EP2305808A1 deoxy-UTP SCHEMBL8003 ZINC8215971 2'-deoxyuridine 5'-(tetrahydrogen triphosphate) 2'-Deoxyuridine-5'-triphosphoric acid = dUTP AN-8236 CHEBI:17625 DEOXYURIDINE-5'-TRIPHOSPHATE Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, (3aS-(3aalpha,4beta,6aalpha))- 102814-08-4 2'-Deoxyuridine-5'-triphosphate sodium salt D01PSS N(4) MO-Dctp Uridine, 2'-deoxy-, 5'-triphosphate 2'-deoxy-UTP 2'-Deoxyuridine-5'-triphosphorate AC1L22IV BDBM50205416 Deoxyuridine 5'-triphosphate Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy- [[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate ((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate 2'-Deoxyuridine 5'-triphosphate 2,4(1H,3H)-pyrimidinedione, 1-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-beta-D-erythro-pentofuranosyl]- DUT Uridine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate) 1173-82-6 2'-Deoxyuridine-5'-triphosphate trisodium salt 84772-EP2295414A1 [ Show all ]
Inchi Key	AHCYMLUZIRLXAA-SHYZEUOFSA-N
Inchi ID	InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
PubChem CID	65070
ChEMBL	CHEMBL374361
IUPHAR	N/A
BindingDB	50205416
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1080.0 nM	PMID17302398	BindingDB,ChEMBL

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