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GPCR

NameC-C chemokine receptor type 8
SpeciesHomo sapiens (Human)
GeneCCR8
SynonymGPRCY6
GPR-CY6
CMKBRL2
CKR-L1
ChemR1
[ Show all ]
DiseasePsoriasis
Length355
Amino acid sequenceMDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
UniProtP51685
Protein Data BankN/A
GPCR-HGmod modelP51685
3D structure modelThis predicted structure model is from GPCR-EXP P51685.
BioLiPN/A
Therapeutic Target DatabaseT20575
ChEMBLCHEMBL4596
IUPHAR65
DrugBankN/A

Ligand

Name4'-Chloro-2,2':6',2''-terpyridine
Molecular formulaC15H10ClN3
IUPAC name4-chloro-2,6-dipyridin-2-ylpyridine
Molecular weight267.716
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.0
Synonyms4'-Chloro-2,2' : 6',2"-terpyridine
4'-chloro-2.2':6'.2''-terpyridine
4-chloro-2,6-bis(pyridin-2-yl)pyridine
AJ-08457
CHEMBL2205805
[ Show all ]
Inchi KeyAHEMFMCEBIJRMU-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H10ClN3/c16-11-9-14(12-5-1-3-7-17-12)19-15(10-11)13-6-2-4-8-18-13/h1-10H
PubChem CID667748
ChEMBLCHEMBL2205805
IUPHARN/A
BindingDB50401354
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50390.0 nMPMID22957890BindingDB,ChEMBL
EC50398.11 nMPMID22957890BindingDB,ChEMBL
FC3.4 -PMID22957890ChEMBL
Ratio EC50106.0 -PMID22957890ChEMBL

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