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GPCR

NameProteinase-activated receptor 2
SpeciesHomo sapiens (Human)
GeneF2RL1
SynonymProtease-activated receptor-2
PAR2
PAR-2
GPR11
G-protein coupled receptor 11
[ Show all ]
DiseaseN/A
Length397
Amino acid sequenceMRSPSAAWLLGAAILLAASLSCSGTIQGTNRSSKGRSLIGKVDGTSHVTGKGVTVETVFSVDEFSASVLTGKLTTVFLPIVYTIVFVVGLPSNGMALWVFLFRTKKKHPAVIYMANLALADLLSVIWFPLKIAYHIHGNNWIYGEALCNVLIGFFYGNMYCSILFMTCLSVQRYWVIVNPMGHSRKKANIAIGISLAIWLLILLVTIPLYVVKQTIFIPALNITTCHDVLPEQLLVGDMFNYFLSLAIGVFLFPAFLTASAYVLMIRMLRSSAMDENSEKKRKRAIKLIVTVLAMYLICFTPSNLLLVVHYFLIKSQGQSHVYALYIVALCLSTLNSCIDPFVYYFVSHDFRDHAKNALLCRSVRTVKQMQVSLTSKKHSRKSSSYSSSSTTVKTSY
UniProtP55085
Protein Data Bank5ndz, 5ndd
GPCR-HGmod modelP55085
3D structure modelThis structure is from PDB ID 5ndz.
BioLiPBL0377325, BL0377326
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5963
IUPHAR348
DrugBankN/A

Ligand

NameCHEMBL3924586
Molecular formulaC30H38N4O4
IUPAC nameN-[(2S)-3-cyclohexyl-1-[(2-methyl-1-oxo-1-spiro[indene-1,4'-piperidine]-1'-ylpropan-2-yl)amino]-1-oxopropan-2-yl]-1,2-oxazole-5-carboxamide
Molecular weight518.658
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP5.3
SynonymsN/A
Inchi KeyATDSIOKSRNTBTG-DEOSSOPVSA-N
Inchi IDInChI=1S/C30H38N4O4/c1-29(2,28(37)34-18-15-30(16-19-34)14-12-22-10-6-7-11-23(22)30)33-26(35)24(20-21-8-4-3-5-9-21)32-27(36)25-13-17-31-38-25/h6-7,10-14,17,21,24H,3-5,8-9,15-16,18-20H2,1-2H3,(H,32,36)(H,33,35)/t24-/m0/s1
PubChem CID134141750
ChEMBLCHEMBL3924586
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition10.0 %PMID27994760ChEMBL

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