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GPCR

NameGalanin receptor type 1
SpeciesHomo sapiens (Human)
GeneGALR1
SynonymGAL1-R
GALNR
GALNR1
GALR-1
GAL1 receptor
DiseaseEpileptic seizures
Length349
Amino acid sequenceMELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProtP47211
Protein Data BankN/A
GPCR-HGmod modelP47211
3D structure modelThis predicted structure model is from GPCR-EXP P47211.
BioLiPN/A
Therapeutic Target DatabaseT78581
ChEMBLCHEMBL4894
IUPHAR243
DrugBankN/A

Ligand

NameCHEMBL3961540
Molecular formulaC23H27NO6S2
IUPAC name2-butoxy-N-[2-phenyl-1-(1,1,4,4-tetraoxo-2,3-dihydro-1,4-dithiin-5-yl)ethyl]benzamide
Molecular weight477.59
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP3.3
SynonymsN/A
Inchi KeyAWFOBYWKVZYQKK-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H27NO6S2/c1-2-3-13-30-21-12-8-7-11-19(21)23(25)24-20(16-18-9-5-4-6-10-18)22-17-31(26,27)14-15-32(22,28)29/h4-12,17,20H,2-3,13-16H2,1H3,(H,24,25)
PubChem CID134155181
ChEMBLCHEMBL3961540
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501000.0 nMNoneChEMBL

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