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GLASS

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GPCR

Name	Prostaglandin D2 receptor 2
Species	Homo sapiens (Human)
Gene	PTGDR2
Synonym	CD294 prostaglandin D2 receptor 2 PGD2 receptor Gpr44 G-protein coupled receptor 44 G protein-coupled receptor 44 DP2 receptor CRTH2 Chemoattractant receptor-homologous molecule expressed on Th2 cells [ Show all ]
Disease	Asthma; Chronic obstructive pulmonary disease Asthma Allergy Allergic rhinitis Allergic asthma Respiratory disease [ Show all ]
Length	395
Amino acid sequence	MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
UniProt	Q9Y5Y4
Protein Data Bank	6d27, 6d26
GPCR-HGmod model	Q9Y5Y4
3D structure model	This structure is from PDB ID 6d27.
BioLiP	BL0428440, BL0428439
Therapeutic Target Database	T61722
ChEMBL	CHEMBL5071
IUPHAR	339
DrugBank	BE0003561

Ligand

Name	alprostadil
Molecular formula	C20H34O5
IUPAC name	7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Molecular weight	354.487
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.2
Synonyms	Prostandin s1508 SR-01000597593-1 Topiglan Vitaros PGE-1 Prink Prostaglandin E1, >=98% (HPLC), synthetic BPBio1_001293 (+)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoate Caverject (13E)-(15S)-11,15-dihydroxy-9-oxoprost-13-enoate CS-1905 11,15-Dihydroxy-9-oxoprost-13-en-1-oate DSSTox_GSID_22578 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoic acid FemLife 7-[(1r,3r)-3-Hydroxy-2-[(1e,3s)-3-Hydroxyoct-1-En-1-Yl]-5-Oxocyclopentyl]heptanoic Acid HMS1989K10 AB00514004-08 HY-B0131 Liprostin Alprostadil, meets USP testing specifications MR-256 BCP01740 NCGC00025234-05 Prostin VR Pediatric SAM001247093 SR-01000946253 U-10,136 XPG PGE1, Prostaglandin E1, powder Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11.alpha.,13E,15S)- Prostaglandin E1, synthetic, powder, BioReagent, suitable for cell culture BRD-K52459643-001-17-7 (-)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoic acid CCG-101188 (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoic acid D00180 119314-69-1 Edex GTPL1882 745P653 HMS2098K17 AC-6095 l-3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid Alprostadil Prostoglandin E1 Minprog Alprostadilum [INN-Latin] NC00438 Befar Prostaglandin-E1 RayVa SMR000112594 Sugiran Vasaprostan Prestwick2_001018 Prostaglandin E1 BIDD:GT0747 C04741 (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid CHEMBL495 (13E,15S)-11alpha,15-dihydroxy-9-oxoprost-13-en-1-oic acid 22299-37-2 EX-A1411 7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)heptanoic acid HMS1571K17 AB00514004 HMS3648O17 AKOS015961103 Lipo-alprostadil Alprostadil(usan) MolPort-003-939-183 B2154 NCGC00025234-03 Prostavasin SAM001246840 SR-01000597593-5 Tox21_110482 Vitaros (TN) PGE1 Prink (TN) Prostaglandin E1, >=99.0% (TLC) BRD-K52459643-001-06-0 (+)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoic acid Caverject (TN) (13E)-(15S)-11,15-dihydroxy-9-oxoprost-13-enoic acid Cyclopentaneheptanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, (-)- 11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid DSSTox_RID_76640 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid Femprox 7-[5-((1E)(3S)-3-hydroxyoct-1-enyl)(1R,4R,5R)-4-hydroxy-2-oxocyclopentyl]hepta noic acid HMS2052L11 AB00514004_09 IDI1_033958 Alprostadil (JP15/USP/INN) LMFA03010134 Alprostadil, United States Pharmacopeia (USP) Reference Standard Muse BCP9000277 NSC 165559 Prostin VR pediatric (TN) SCHEMBL33317 SR-01000946253-1 U-10136 ZINC3813088 PGE1;Prostaglandin E1 Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)- Prostaglandin E1; PGE1 BSPBio_001175 (-)-Protaglandin E1 CHEBI:15544 (13E)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate D0I4DQ 11alpha,15alpha-Dihydroxy-9-oxo-13-trans-prostenoic acid Edex (TN) 50865-30-0 HEI-507 9-oxo-11R,15S-dihydroxy-13E-prostaenoic acid HMS3268I09 AC1NQXHQ l-PGE1 Alprostadil [USAN:USP:INN:BAN:JAN] MLS000758964 Alprox-TD NCGC00016535-01 Befar (TN) Prostaglandine E RP17688 SR-01000597593 SYN3025 Viridal Prestwick3_001018 Prostaglandin E1, 98+% BML1-F06 CAS-745-65-3 (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid CPD000112594 (1R,2R,3R)-3-Hydroxy-2-((E)-(3S)-3-hydroxy-1-octenyl)-5-oxocyclopentaneheptanoic acid DSSTox_CID_2578 3-Hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentaneheptanoate F5TD010360 7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid HMS1791K10 AB00514004-06 HMS3715K17 Alista Lipoprost Alprostadil, European Pharmacopoeia (EP) Reference Standard MR 256 BC205461 NCGC00025234-04 Prostin VR SAM001246845 SR-01000597593-6 U 10136 W-104416 PGE1 Oligomer Promostan Prostaglandin E1, powder, gamma-irradiated, BioXtra, suitable for cell culture ONO 1608 BRD-K52459643-001-10-2 (-)-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-Cyclopentaneheptanoate Caverject Impulse (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate Cyclopentaneheptanoic acid, 3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-, l- 11,15-dihydroxy-9-oxoprost-13-en-1-oic acid (ACD/Name 4.0) DTXSID9022578 50-83-9 GMVPRGQOIOIIMI-DWKJAMRDSA-N 745-65-3 HMS2090L08 AB2000131 K274 Alprostadil (JP17/USP/INN) MFCD00077860 Alprostadilum Muse (TN) BDBM50101853 Prostaglandin E1;Edex;Muse;Liprostin;Caverject Prostivas SMP2_000271 ST50826271 UNII-F5TD010360 PGE1alpha Prost-13-en-1-oic acid, 11,15-dihydroxy-9-oxo-, (11alpha,13E,15S)-, homopolymer BSPBio_001488 (11?,13E,15S)-11,15-Dihydroxy-9-oxo-prost-13-en-1-oic acid (13e)-(15s)-11alpha,15-dihydroxy-9-oxoprost-13-enoic acid D0N2EF EINECS 212-017-2 7-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)-5-oxocyclopentyl)heptanoic acid HMS1361K10 AB0014134 HMS3402K10 AI3-62116 l-Prostaglandin E1 Alprostadil(Caverject) MLS001424250 AS-16360 NCGC00025234-02 BG0025 [ Show all ]
Inchi Key	GMVPRGQOIOIIMI-DWKJAMRDSA-N
Inchi ID	InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID	5280723
ChEMBL	CHEMBL495
IUPHAR	1882
BindingDB	50101853
DrugBank	DB00770
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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