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GPCR

NameD(4) dopamine receptor
SpeciesMus musculus (Mouse)
GeneDrd4
Synonymd(2C) dopamine receptor
D4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
DiseaseN/A for non-human GPCRs
Length387
Amino acid sequenceMGNSSATEDGGLLAGRGPESLGTGAGLGGAGAAALVGGVLLIGLVLAGNSLVCVSVASERTLQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVASPVVCGLNDVPGRDPAVCCLENRDYVVYSSVCSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPFFPDCPPPLPSLRTSPSDSSRPESELSQRPCSPGCLLADAALPQPPEPSSRRRRGAKITGRERKAMRVLPVVVGAFLVCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProtP51436
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2574
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3986799
Molecular formulaC22H29N3O2
IUPAC name(2S)-4-[2-(2,3-dihydroindol-1-yl)ethyl]-2-[(2,4-dimethylpyridin-3-yl)oxymethyl]morpholine
Molecular weight367.493
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP3.2
SynonymsN/A
Inchi KeyHPLSCEVPHLQHEB-FQEVSTJZSA-N
Inchi IDInChI=1S/C22H29N3O2/c1-17-7-9-23-18(2)22(17)27-16-20-15-24(13-14-26-20)11-12-25-10-8-19-5-3-4-6-21(19)25/h3-7,9,20H,8,10-16H2,1-2H3/t20-/m0/s1
PubChem CID134156440
ChEMBLCHEMBL3986799
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki4947.0 nMNoneChEMBL

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