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GLASS

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GPCR

Name	G-protein coupled estrogen receptor 1
Species	Homo sapiens (Human)
Gene	GPER1
Synonym	Chemoattractant receptor-like 2 Gpr41 IL8-related receptor DRY12 LERGU LERGU2 LYGPR Lymphocyte-derived G-protein coupled receptor Membrane estrogen receptor mER GPR30 GPGR GPER chemokine receptor-like 2 CMKRL2 DRY12 FEG-1 Flow-induced endothelial G-protein coupled receptor 1 G protein-coupled estrogen receptor 1 G-protein coupled receptor 30 CEPR GPCR-BR [ Show all ]
Disease	N/A
Length	375
Amino acid sequence	MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
UniProt	Q99527
Protein Data Bank	N/A
GPCR-HGmod model	Q99527
3D structure model	This predicted structure model is from GPCR-EXP Q99527.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5872
IUPHAR	221
DrugBank	BE0003446

Ligand

Name	MK-0354
Molecular formula	C7H8N6
IUPAC name	3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Molecular weight	176.183
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	0.2
Synonyms	3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole Cyclopenta(C)pyrazole, 1,4,5,6-tetrahydro-3-(1H-tetrazol-5-yl)- MK 0354 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole BCP18112 NCGC00263122-01 1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole(MK-0354) 5-{1H,4H,5H,6H-CYCLOPENTA[C]PYRAZOL-3-YL}-1H-1,2,3,4-TETRAZOLE CHEMBL456145 KB-78878 UNII-4U62D8JYIQ 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole 851776-28-8 D0A5MR 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[d]pyrazole BDBM50273099 GTPL5784 NCGC00263122-02 1,4,5,6-tetrahydro-3-(2H-tetrazol-5-yl)Cyclopentapyrazole CS-4589 LTQYSJKGRPGMPO-UHFFFAOYSA-N ZINC38312374 3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopentapyrazole AKOS030526928 DA-02747 MolPort-009-683-033 1,4,5,6-Tetrahydro-3-(1H-tetrazol-5-yl)cyclopenta[c]pyrazole 4U62D8JYIQ HY-13008 SCHEMBL1875705 [ Show all ]
Inchi Key	LTQYSJKGRPGMPO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C7H8N6/c1-2-4-5(3-1)8-9-6(4)7-10-12-13-11-7/h1-3H2,(H,8,9)(H,10,11,12,13)
PubChem CID	11159621
ChEMBL	CHEMBL456145
IUPHAR	5784
BindingDB	50273099
DrugBank	DB05939
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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