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Name | 5-hydroxytryptamine receptor 5A |
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Species | Homo sapiens (Human) |
Gene | HTR5A |
Synonym | 5-HT5alpha 5-HT-5 MR22 Htr5 5-HT-5A [ Show all ] |
Disease | N/A |
Length | 357 |
Amino acid sequence | MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH |
UniProt | P47898 |
Protein Data Bank | N/A |
GPCR-HGmod model | P47898 |
3D structure model | This predicted structure model is from GPCR-EXP P47898. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3426 |
IUPHAR | 10 |
DrugBank | BE0004688 |
Name | CHEMBL188440 |
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Molecular formula | C36H40F3N3O4S |
IUPAC name | (E)-N-[2-(dimethylamino)ethyl]-2-phenyl-N-[[4-[4-[(2-phenylethylamino)methyl]phenyl]phenyl]methyl]ethenesulfonamide;2,2,2-trifluoroacetic acid |
Molecular weight | 667.788 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 2 |
XlogP | None |
Synonyms | N/A |
Inchi Key | AHFZKVQLXINPHE-LIUXSCBKSA-N |
Inchi ID | InChI=1S/C34H39N3O2S.C2HF3O2/c1-36(2)24-25-37(40(38,39)26-22-30-11-7-4-8-12-30)28-32-15-19-34(20-16-32)33-17-13-31(14-18-33)27-35-23-21-29-9-5-3-6-10-29;3-2(4,5)1(6)7/h3-20,22,26,35H,21,23-25,27-28H2,1-2H3;(H,6,7)/b26-22+; |
PubChem CID | 44397592 |
ChEMBL | CHEMBL188440 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 251.19 nM | PMID16002289 | ChEMBL |
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