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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled estrogen receptor 1
Species	Homo sapiens (Human)
Gene	GPER1
Synonym	Chemoattractant receptor-like 2 Gpr41 IL8-related receptor DRY12 LERGU LERGU2 LYGPR Lymphocyte-derived G-protein coupled receptor Membrane estrogen receptor mER GPR30 GPGR GPER chemokine receptor-like 2 CMKRL2 DRY12 FEG-1 Flow-induced endothelial G-protein coupled receptor 1 G protein-coupled estrogen receptor 1 G-protein coupled receptor 30 CEPR GPCR-BR [ Show all ]
Disease	N/A
Length	375
Amino acid sequence	MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
UniProt	Q99527
Protein Data Bank	N/A
GPCR-HGmod model	Q99527
3D structure model	This predicted structure model is from GPCR-EXP Q99527.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5872
IUPHAR	221
DrugBank	BE0003446

Ligand

Name	estradiol cypionate
Molecular formula	C26H36O3
IUPAC name	[(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] 3-cyclopentylpropanoate
Molecular weight	396.571
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	7.1
Synonyms	Estradiol (cypionate) Estradiol 17.beta.-cylopentylpropionate 1,3,5(10)-Estratriene-3,17beta-diol 17-cyclopentylpropionate Estradiol cypionate (USP) 17beta-Estradiol 17-cypionate HMS2234K11 AC1L1SYP NCGC00013034-01 BRN 3171075 NSC-3354 Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17.beta.-yl ester Tox21_112331 Depo-estradiol (TN) DSSTox_RID_76824 Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 17-cyclopentanepropanoate Estradiol 17-cyclopentanepropionate (17.beta.)-Estra-1,3,5(10)-triene-3,17-diol 17.beta.-cyclopentanepropanoate Estradiol 17beta-cyclopentylpropionate 17.beta.-Estradiol cyclopentanepropionate Estradiol cypionate, United States Pharmacopeia (USP) Reference Standard 3,17\|A-Hydroxy-1,3,5(10)-estratriene 17-cyclopentylpropionate LS-64732 ANW-43364 NCGC00166134-03 CAS-313-06-4 s4046 UNII-7E1DV054LO Depoestradiol E. Ionate P.A. Estra-1,3,5(10)-triene-3,17-diol, (17beta)-, 17-cyclopentanepropanoate Estra-1,5(10)-triene-3,17-diol, (17.beta.)-, 17-cyclopentanepropanoate Estradiol 17.beta.-cyclopentanepropionate (1S,11S,14S,15S,10R)-5-hydroxy-15-methyltetracyclo[8.7.0.0<2,7>.0<11,15>]hepta deca-2,4,6-trien-14-yl 3-cyclopentylpropanoate Estradiol cyclopentylpropionate 17.beta.-[(3-Cyclopentylpropanoyl)oxy]estra-1,3,5(10)-trien-3-ol Estro-Depo 4-09-00-00047 (Beilstein Handbook Reference) MLS001074891 beta-Estradiol 17-Cyclopentylpropionate Neoginon Depositum CS-4691 ST075189 depGynogen ZINC3876078 DSSTox_CID_2999 ECP (VAN) estradiol 17 beta-cyclopentylpropionate Estradiol 17.beta.-cypionate 1,3,5(10)-Estratriene-3,17\|A-diol 17-cyclopentylpropionate Estradiol cypionate [USAN] 17\|A-Estradiol-17-cypionate HY-B1100 ACN-032014 NCGC00166134-01 C14640 NSC3354 Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17beta-yl ester Tox21_112331_1 Depo-estradiol cyclopentylpropionate DTXSID4022999 Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 17-cyclopentanepropanoate Estradiol 17-cyclopentylpropionate (17?)-3-Hydroxyestra-1,3,5(10)-trien-17-yl 3-cyclopentylpropanoate Estradiol 17beta-cylopentylpropionate 17.beta.-Estradiol cyclopentylpropionate Estradiol, 17-cyclopentanepropionate 313-06-4 MFCD00056558 API0002258 NCGC00255333-01 CHEBI:34745 SCHEMBL41551 Dep-Estro UOACKFBJUYNSLK-XRKIENNPSA-N Depoestradiol cypionate E0875 Estra-1,3,5(10)-triene-3,17beta-diol 17-(cyclopentanepropionate) Estradep Estradiol 17.beta.-cyclopentylpropionate (8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl 3-cyclopentylpropanoate 17beta-Estradiol 17-cyclopentylpropionate Femogen CYP 7E1DV054LO MolPort-003-941-327 beta-Estradiol 17-cypionate NSC 3354 Cyclopentanepropionic acid, 17-ester with estradiol Tox21_110003 Depo-Estradiol [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] 3-cyclopentylpropanoate DSSTox_GSID_22999 EINECS 206-237-8 estradiol 17 beta-cypionate Estradiol 17beta-cyclopentanepropionate 17.beta.-Estradiol 17-cyclopentylpropionate Estradiol cypionate [USP] 3,17beta-Hydroxy-1,3,5(10)-estratriene 17-cyclopentylpropionate KS-5296 AKOS015895730 NCGC00166134-02 C26H36O3 Pertradiol D04063 Tox21_301818 Depoestra E. Ionate P.A Estra-1,3,5(10)-triene-3,17-diol(17b)-, 17-cyclopentanepropanoate Estra-1,5(10)-triene-3,17-diol (17.beta.)-, 17-cyclopentanepropanoate Estradiol 17-cypionate (17beta)-3-hydroxyestra-1(10),2,4-trien-17-yl 3-cyclopentylpropanoate Estradiol 17beta-cypionate 17.beta.-Estradiol cypionate Estrapo 313D064 MLS000069763 BCP11930 NCI60_002938 CHEMBL1200973 SMR000058700 Depestro W-106910 Depofemin EBD2157881 [ Show all ]
Inchi Key	UOACKFBJUYNSLK-XRKIENNPSA-N
Inchi ID	InChI=1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1
PubChem CID	9403
ChEMBL	N/A
IUPHAR	N/A
BindingDB	N/A
DrugBank	DB13954
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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