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GPCR

Name	Alpha-1B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1b
Synonym	adrenergic receptor alpha 1B-adrenoceptor alpha 1B-adrenoreceptor adrenergic alpha 1B receptor Alpha-1B adrenoceptor Alpha-1B adrenoreceptor alpha1B-adrenergic receptor alpha1B-adrenoceptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	515
Amino acid sequence	MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLPSASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESPGTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
UniProt	P15823
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL315
IUPHAR	23
DrugBank	N/A

Ligand

Name	lorazepam
Molecular formula	C15H10Cl2N2O2
IUPAC name	7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Molecular weight	321.157
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	2.4
Synonyms	Ativan (TN) Lorazepam Fabra BRD-A11990600-001-01-8 Lorazepam Medix Brand ct-Arzneimittel Brand of Lorazepam Lorazepam ratiopharm Brand Desitin Brand of Lorazepam (+/-)-Lorazepam DTXSID7023225 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- FT-0670847 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one Kalmalin 7-chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one Lopam AKOS015904303 Loraz Aplacasse Lorazepam 0.1 mg/ml in Acetonitrile Somagerol Lorazepam, British Pharmacopoeia (BP) Reference Standard Trapax Lorazepamum [INN-Latin] Wyeth, Orfidal Lorsedal Medix Brand of Lorazepam neuraxpharm Brand of Lorazepam Novopharm Brand of Lorazepam NuLoraz ratiopharm Brand of Lorazepam Sedazin Lorazepam Apotex Brand Baxter Brand of Lorazepam Lorazepam Intensol CCG-101170 Lorazepam Novartis Brand D0E0OG Dolorgiet Brand of Lorazepam 2H,1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- Efasedan 7-chloranyl-5-(2-chlorophenyl)-3-oxidanyl-1,3-dihydro-1,4-benzodiazepin-2-one HMS3394H07 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one. L1764_SIGMA 846-49-1 Loram AN-20537 lorazep von ct Apo-Lorazepam Temesta Lorazepam-Efeka WLN: T67 GMV JN IHJ CG IQ KR BG Lorazin Lozepam MLS001424236 Novartis Brand of Lorazepam NSC289758 Orfidal Rocosgen Serra Pamies Brand of Lorazepam Aripax Lorazepam Desitin Brand Bonatranquan Lorazepam Medical CPD000058410 Lorazepam preservative free Delormetazepam DSSTox_GSID_23225 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy- Emotival 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one Idalprem 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one Llorens Brand of Lorazepam AC1L1H3H Lorat Anzepam Lorazepam (JP15/USP/INN) Sinestron Lorazepam [USAN:INN:BAN:JAN] Tox21_111669 LORAZEPAM7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one WY4036 Loridem Medical Brand of Lorazepam Nervistop L Novo-Lorazem Nu-Loraz Punktyl Securit Ativan and others Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard BRN 0759084 Lorazepam neuraxpharm CTK3E8194 Lorazepam Riemser Brand DivK1c_000965 (.+/-.)-Lorazepam Duralozam 5-25-02-00248 (Beilstein Handbook Reference) GTPL5884 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one KBio1_000965 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one Lorabenz Almazine Lorazene Aplacassee Lorazepam 1.0 mg/ml in Acetonitrile Stapam Lorazepam, European Pharmacopoeia (EP) Reference Standard Upan Lorazepan Chobet Wypax Lorsilan Merck dura Brand of Lorazepam NINDS_000965 NSC 289758 o-Chlorooxazepam Renaquil Sedicepan Lorazepam Baxter Brand BCP13713 Lorazepam Lannacher CHEBI:6539 Lorazepam Novopharm Brand DB00186 Donix 2H-1, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy- EINECS 212-687-6 7-chloro-3-hydroxy-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one HMS503A11 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one Larpose 846L491 Lorans Anxiedin ApoLorazepam Lorazepam solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material Temesta (TN) Lorazepam-neuraxpharm Wy 4036 Lorazon LS-34141 NC00420 Novhepar Nu Loraz Orfidal Wyeth SAM001246833 Sidenar Ativan Lorazepam Dolorgiet Brand Bonton Lorazepam Medical Brand ct Arzneimittel Brand of Lorazepam Lorazepam ratiopharm Demethyllormetazepam (+-)-7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one DSSTox_RID_76932 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-, (+-)- Equitam 7-Chloro-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one (lorazepam) IDI1_000965 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-benzo[e][1,4]diazepin-2(3H)-one Lomesta AHP Brand of Lorazepam Lorax API0001556 Lorazepam (JP17/USP/INN) SMR000058410 Lorazepam [USAN:USP:INN:BAN:JAN] Tranqipam Lorazepamum Wyeth Brand of Lorazepam Lorivan Medical, Lorazepam Nervistopl Novolorazem Nu-Pharm Brand of Lorazepam Quait Sedatival Lorazepam AHP Brand Azurogen Lorazepam Genericon CAS-846-49-1 Lorazepam neuraxpharm Brand D00365 DIWRORZWFLOCLC-UHFFFAOYSA-N (RS)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one Durazolam HMS2052H07 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one L-230 7-Chloro-5-(o-chlorophenyl)-1,4-benzodiazepin-2-one Lorafen Alzapam Lorazep Apo Lorazepam Tavor Lorazepam, United States Pharmacopeia (USP) Reference Standard Vigiten Lorazepan Richet Lorzem Merlit Norlormetazepam NSC-289758 o-Chloroxazepam Riemser Brand of Lorazepam Sedizepan Lorazepam ct-Arzneimittel Brand BDBM50292627 Lorazepam Llorens Brand CHEMBL580 Lorazepam Nu-Pharm Brand DEA No. 2885 DSSTox_CID_3225 2H-1, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy- Emotion 7-chloro-3-hydroxy-5-(2'-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-one I14-16542 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one # Laubeel A840886 Lorapam Anxira lorazepam (Ativan) Apotex Brand of Lorazepam Silence Lorazepam Wyeth Brand Tolid Lorazepam-ratiopharm Wy-4036 Lorenin Max Pax NCGC00159439-02 Novo Lorazem Nu Pharm Brand of Lorazepam Pro dorm SCHEMBL26961 [ Show all ]
Inchi Key	DIWRORZWFLOCLC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
PubChem CID	3958
ChEMBL	N/A
IUPHAR	5884
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	170000.0 nM	PMID10565838	IUPHAR

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