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GPCR

NameG-protein coupled receptor 3
SpeciesHomo sapiens (Human)
GeneGPR3
Synonymadenylate cyclase constitutive activator
G protein-coupled receptor R4
ACCA orphan receptor
Gpcr21
GPCR3
[ Show all ]
DiseaseN/A
Length330
Amino acid sequenceMMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV
UniProtP46089
Protein Data BankN/A
GPCR-HGmod modelP46089
3D structure modelThis predicted structure model is from GPCR-EXP P46089.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR83
DrugBankN/A

Ligand

NameSphingosine 1-phosphate
Molecular formulaC18H38NO5P
IUPAC name[(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
Molecular weight379.478
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP1.9
SynonymsC18-Sphingosine 1-phosphate
D-erythro-Sphingosine-1-phosphate
LMSP01050001
SCHEMBL2559423
Sphingosine 1-phosphate, >=98.0% (TLC)
[ Show all ]
Inchi KeyDUYSYHSSBDVJSM-KRWOKUGFSA-N
Inchi IDInChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
PubChem CID5283560
ChEMBLCHEMBL225155
IUPHAR911
BindingDB50158348
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5019.9526 - 79.4328 nMPMID12220620IUPHAR

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