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GPCR

Name	G-protein coupled receptor 183
Species	Homo sapiens (Human)
Gene	GPR183
Synonym	EBI2 {ECO:0000303\|PubMed:8383238} lymphocyte-specific G protein-coupled receptor hEBI2 {ECO:0000303\|PubMed:22875855} GPR183 G protein-coupled receptor 183 EBI2 Epstein-Barr virus-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G-protein coupled receptor 2 {ECO:0000303\|PubMed:8383238} EBV-induced G protein-coupled receptor 2 Epstein-Barr virus-induced gene 2 [ Show all ]
Disease	N/A
Length	361
Amino acid sequence	MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
UniProt	P32249
Protein Data Bank	N/A
GPCR-HGmod model	P32249
3D structure model	This predicted structure model is from GPCR-EXP P32249.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259470
IUPHAR	81
DrugBank	N/A

Ligand

Name	27-hydroxycholesterol
Molecular formula	C27H46O2
IUPAC name	(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
Molecular weight	402.663
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	7.1
Synonyms	(25R)-26-Hydroxycholesterol (3S,8S,9S,10R,13R,14S,17R)-17-((2R,6R)-7-Hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 6T2NA6P5SQ Cholest-5-ene-3-b,27-diol GTPL2752 (3-beta)-cholest-5-ene-3,26-diol 20380-11-4 27HC BDBM20183 Cholest-5-ene-3beta,26-diol, (25R)- LMST01010088 (1S,2R,5S,10S,11S,14R,15R)-14-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-2,15-dimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadec-7-en-5-ol (3beta,25R)-Cholest-5-ene-3,26,diol 27 OHC 5-cholestene-3 beta,27-diol cholest-(25R)-5-en-3beta,26-diol D0H2YM UNII-6T2NA6P5SQ (25R)-Cholest-5-ene-3b,26-diol (3S,8S,9S,10R,13R,14S,17R)-17-[(1R,5R)-6-hydroxy-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 27-OHC AC1L3XNP Cholest-5-ene-3-beta,26-diol HY-N2371 (3?,25R)-Cholest-5-ene-3,26-diol 26-hydroxycholesterol(25R) 380C114 CHEBI:76591 Cholest-5-ene-3beta,27-diol MolPort-042-624-515 (25R)-26-Hydroxycholesterol (3beta,25R)-cholest-5-ene-3,26-diol 27-hydroxy-cholesterol(25R) 5-cholestene-3beta,27-diol Cholest-5-ene-3,26,diol, (3beta,25R)- FYHRJWMENCALJY-YSQMORBQSA-N ZINC4097086 (25R)-Cholest-5-ene-3beta,26-diol (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,6R)-7-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol AKOS027381276 Cholest-5-ene-3-beta,27-diol J-013261 (3b,25R)-Cholest-5-ene-3,26-diol 27 HC 5,25R-Cholesten-3beta,26-diol CHEMBL353882 CS-6949 SCHEMBL288494 [ Show all ]
Inchi Key	FYHRJWMENCALJY-YSQMORBQSA-N
Inchi ID	InChI=1S/C27H46O2/c1-18(17-28)6-5-7-19(2)23-10-11-24-22-9-8-20-16-21(29)12-14-26(20,3)25(22)13-15-27(23,24)4/h8,18-19,21-25,28-29H,5-7,9-17H2,1-4H3/t18-,19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
PubChem CID	123976
ChEMBL	N/A
IUPHAR	2752
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3029.0 nM	PMID21796211	IUPHAR

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