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GPCR

NameProstaglandin E2 receptor EP3 subtype
SpeciesRattus norvegicus (Rat)
GenePtger3
SynonymEP3 receptor
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3
prostanoid EP3 receptor
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWSDQLER
UniProtP34980
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5674
IUPHAR342
DrugBankN/A

Ligand

Namealprostadil
Molecular formulaC20H34O5
IUPAC name7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]heptanoic acid
Molecular weight354.487
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP3.2
SynonymsCaverject
(13E)-(15S)-11,15-dihydroxy-9-oxoprost-13-enoate
CS-1905
11,15-Dihydroxy-9-oxoprost-13-en-1-oate
DSSTox_GSID_22578
[ Show all ]
Inchi KeyGMVPRGQOIOIIMI-DWKJAMRDSA-N
Inchi IDInChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
PubChem CID5280723
ChEMBLCHEMBL495
IUPHAR1882
BindingDB50101853
DrugBankDB00770

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC500.45 nMPMID9537820IUPHAR
Ki1.0 nMPMID9537820IUPHAR

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