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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesMus musculus (Mouse)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length388
Amino acid sequenceMDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPSDT
UniProtP97288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2183
IUPHAR9
DrugBankN/A

Ligand

NameRenzapride
Molecular formulaC16H22ClN3O2
IUPAC name4-amino-N-[(4S,5S)-1-azabicyclo[3.3.1]nonan-4-yl]-5-chloro-2-methoxybenzamide
Molecular weight323.821
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.1
Synonyms(( -)-endo)-4-Amino-5-chloro-2-methoxy-N-(1-azabicyclo(3.3.1)non-4-yl)benzamide
AKOS015909829
LS-187513
UNII-9073C0W4E9 component GZSKEXSLDPEFPT-HZMBPMFUSA-N
4-Amino-N-1-azabicyclo(3.3.1)non-4-yl-5-chloro-2-methoxybenzamide endo-
[ Show all ]
Inchi KeyGZSKEXSLDPEFPT-HZMBPMFUSA-N
Inchi IDInChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-14-4-6-20-5-2-3-10(14)9-20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)/t10-,14-/m0/s1
PubChem CID3086547
ChEMBLN/A
IUPHAR244
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki125.893 nMPMID8946946IUPHAR

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