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GPCR

NameG-protein coupled receptor 35
SpeciesMus musculus (Mouse)
GeneGpr35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A for non-human GPCRs
Length307
Amino acid sequenceMNSTTCNSTLTWPASVNNFFIIYSALLLVLGLLLNSVALWVFCYRMHQWTETRIYMTNLAVADLCLLCSLPFVLYSLKYSSSDTPVCQLSQGIYLANRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAAAVCVALWVIVVTSLVVRWRLGMQEGGFCFSSQTRRNFSTTAFSLLGFYLPLAIVVFCSLQVVTVLSRRPAADVGQAEATQKATHMVWANLAVFVICFLPLHVVLTVQVSLNLNTCAARDTFSRALSITGKLSDTNCCLDAICYYYMAREFQEASKPATSSNTPHKSQDSQILSLT
UniProtQ9ES90
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2390813
IUPHAR102
DrugBankN/A

Ligand

Namekynurenic acid
Molecular formulaC10H7NO3
IUPAC name4-oxo-1H-quinoline-2-carboxylic acid
Molecular weight189.17
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.3
SynonymsHMS1736A10
I14-11091
4-Hydroxyquinaldate
KBio2_004164
4-oxo-1,4-dihydroquinoline-2-carboxylic acid
[ Show all ]
Inchi KeyHCZHHEIFKROPDY-UHFFFAOYSA-N
Inchi IDInChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
PubChem CID3845
ChEMBLCHEMBL299155
IUPHAR2918
BindingDB81975
DrugBankDB11937

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5010964.8 nMPMID16754668IUPHAR

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