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GPCR

Name	Prostaglandin D2 receptor 2
Species	Rattus norvegicus (Rat)
Gene	Ptgdr2
Synonym	PGD2 receptor Gpr44 G protein-coupled receptor 44 DP2 receptor CRTH2 CD294 prostaglandin D2 receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	403
Amino acid sequence	MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD
UniProt	Q6XKD3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075112
IUPHAR	339
DrugBank	N/A

Ligand

Name	Ramatroban
Molecular formula	C21H21FN2O4S
IUPAC name	3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
Molecular weight	416.467
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	2.9
Synonyms	SR-01000883932 3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid ZINC3798772 AC-719 Bay u-3405 BDBM50161746 CTK0H6708 DSSTox_RID_81819 HY-B0745 NCGC00167519-01 Ramatroban (JAN/INN) (R)-3-[3-(4-Fluorophenylsulphonylamino)-1,2,3,4-tetrahydrocarbazol- 9-yl]propionic acid SR-01000946208-1 649F855 [3H]baynas AKOS015966619 BAY-u 3405 CAS-116649-85-5 D0P8TX EN-137774 LDXDSHIEDAPSSA-OAHLLOKOSA-N NCGC00167519-07 (+)-(3R)-3-(p-Fluorobenzenesulfonamido)-1,2,3,4-tetrahydrocarbazole-9-propionic acid RT-011424 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid UNII-P1ALI72U6C A8X Bay u 3405 Baynas (TN) CHEMBL361812 DSSTox_CID_26685 GTPL1911 MLS006010637 (R)-3-(3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydrocarbazol-9-yl)propanoic acid SCHEMBL29030 SR-01000883932-1 3R-[[(4-FLUOROPHENYL)SULFONYL]AMINO]-1,2,3,4-TETRAHYDRO-9H-CARBAZOLE-9-PROPANOICACID [3H]Bay u 3405 AC1L3XGV BAY u3405 C-35509 D01128 DTXSID1046685 J-003466 NCGC00167519-02 Ramatroban [INN:BAN] 116649-85-5 Tox21_112516 9H-Carbazole-9-propanoic acid, 3-(((4-fluorophenyl)sulfonyl)amino)-1,2,3,4-tetrahydro-, (R)- [3H]ramatroban AN-1137 Bay-u-3405 CHEBI:32087 FT-0080313 LS-172326 P1ALI72U6C (+)-(3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid S-7973 3(r)-[[(4-fluoro-phenyl) sulfonyl]amino]-1,2,3,4-tetrahydro-9h-carbazole-9-propanoic acid 3-[(R)-3-(4-Fluoro-benzenesulfonylamino)-1,2,3,4-tetrahydro-carbazol-9-yl]-propionic acid X6873 ABP001095 Bay u 3406 BC228169 CS-2956 DSSTox_GSID_46685 HMS3648E21 MolPort-005-943-701 Ramatroban (BAY u3405) (R)-3-(3-(4-fluorophenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)propanoic acid SMR002530322 SR-01000946208 [3H]BAY u3405 AJ-45646 BAY u3405;BAY-u3405 C21H21FN2O4S D0GC5H EN 137774 KS-1310 NCGC00167519-04 Ramatroban, >=98% (HPLC), solid 3-(4-Fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9-carbazole propanoic acid Tox21_112516_1 9H-Carbazole-9-propanoicacid, 3-[[(4-fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-, (3R)- AOB5536 Baynas DB13036 GTPL1910 MFCD00887606 PubChem9956 (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic Acid SC-00487 [ Show all ]
Inchi Key	LDXDSHIEDAPSSA-OAHLLOKOSA-N
Inchi ID	InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
PubChem CID	123879
ChEMBL	CHEMBL361812
IUPHAR	1911, 1910
BindingDB	50161746
DrugBank	DB13036
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	50.1187 nM	PMID12975488	IUPHAR

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