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GPCR

NameLysophosphatidic acid receptor 1
SpeciesMus musculus (Mouse)
GeneLpar1
SynonymVZG-1 {ECO:0000303|PubMed:8922387, ECO:0000303|PubMed:9600933}
Rec1.3 {ECO:0000303|PubMed:9013780}
Lysophosphatidic acid receptor Edg-2 {ECO:0000303|PubMed:9600933}
lysophosphatidic acid receptor Edg-2
Lpar1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMAAASTSSPVISQPQFTAMNEQQCFYNESIAFFYNRSGKYLATEWNTVSKLVMGLGITVCVFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIDHCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIVCWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRNENPNGPTEGSDRSASSLNHTILAGVHSNDHSVV
UniProtP61793
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3621025
IUPHAR272
DrugBankN/A

Ligand

NameAM095 free acid
Molecular formulaC27H24N2O5
IUPAC name2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid
Molecular weight456.498
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP5.0
SynonymsLysophosphatidic acid antagonists (fibrotic disease), Amira
{4'-[3-Methyl-4-({[(1R)-1-phenylethoxy]carbonyl}amino)-1,2-oxazol-5-yl][1,1'-biphenyl]-4-yl}acetic acid
2-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]acetic acid
AM-152)
D06XGC
[ Show all ]
Inchi KeyLNDDRUPAICPXIN-GOSISDBHSA-N
Inchi IDInChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1
PubChem CID46213949
ChEMBLCHEMBL2182052
IUPHAR6988
BindingDB50398127
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50778.0 nMPMID21159750IUPHAR

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