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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Probable G-protein coupled receptor 132
Species	Homo sapiens (Human)
Gene	GPR132
Synonym	G protein-coupled receptor G2A G2 accumulation protein GPR132
Disease	N/A
Length	380
Amino acid sequence	MCPMLLKNGYNGNATPVTTTAPWASLGLSAKTCNNVSFEESRIVLVVVYSAVCTLGVPANCLTAWLALLQVLQGNVLAVYLLCLALCELLYTGTLPLWVIYIRNQHRWTLGLLACKVTAYIFFCNIYVSILFLCCISCDRFVAVVYALESRGRRRRRTAILISACIFILVGIVHYPVFQTEDKETCFDMLQMDSRIAGYYYARFTVGFAIPLSIIAFTNHRIFRSIKQSMGLSAAQKAKVKHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGDRNAMCGLEERLYTASVVFLCLSTVNGVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTDVTRLTHSRDTEELQSPVALADHYTFSRPVHPPGSPCPAKRLIEESC
UniProt	Q9UNW8
Protein Data Bank	N/A
GPCR-HGmod model	Q9UNW8
3D structure model	This predicted structure model is from GPCR-EXP Q9UNW8.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3085618
IUPHAR	128
DrugBank	N/A

Ligand

Name	9(S)-HODE
Molecular formula	C18H32O3
IUPAC name	(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
Molecular weight	296.451
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.3
Synonyms	42KE04U9BM 9HO alpha-Dimorphecolic acid, (9S)- DB07302 SR-01000946948-1 (9S)-Hydroxyoctadecadienoic acid 9S-hydroxy-10E,12Z-octadecadienoic acid C14767 IDI1_033955 [S-(E,Z)]-9-hydroxy-10,12-Octadecadienoate (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoate 9(S)-hydroxyoctadecadienoic acid alpha-dimorphecolic acid D0C2DG SCHEMBL3188979 (10E,12Z)-(9S)-9-Hydroxyoctadeca-10,12-dienoic acid 10,12-Octadecadienoic acid, 9-hydroxy-, [S-(E,Z)]- 9S-HODE BCBcMAP01_000085 GTPL5567 UNII-42KE04U9BM (9S)-Hydroxyoctadecadinoiec acid 9(S)-HODE, >=98% (HPLC) AC1NSNNN CHEBI:34496 LMFA02000188 [S-(E,Z)]-9-hydroxy-10,12-Octadecadienoic acid (+)-alpha-Dimorphecolic acid (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid 1530AH 9-hydroxyoctadecadienoic acid alpha-Dimorphecolic acid, (+)- D0SZ4T SR-01000946948 (9S)-Hydroxyoctadecadienoate 73543-67-6 9S-hydroxy-10E,12Z-octadecadienoate BML2-D04 HMS1361K07 ZINC4655401 (9s,10e,12z)-9-hydroxy-10,12-octadecadienoic acid 9(S)-Hydroxy-10(E),12(Z)-octadecadienoic acid Alpha-dimorphecolic CHEMBL1230670 NCGC00161316-01 (10E,12Z)-(9S)-9-Hydroxyoctadeca-10,12-dienoate 10,12-Octadecadienoic acid, 9-hydroxy-, (9S,10E,12Z)- [ Show all ]
Inchi Key	NPDSHTNEKLQQIJ-UINYOVNOSA-N
Inchi ID	InChI=1S/C18H32O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h6,8,11,14,17,19H,2-5,7,9-10,12-13,15-16H2,1H3,(H,20,21)/b8-6-,14-11+/t17-/m1/s1
PubChem CID	5312830
ChEMBL	N/A
IUPHAR	5567
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2000.0 nM	PMID16236715	IUPHAR

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