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GPCR

NameProbable G-protein coupled receptor 132
SpeciesHomo sapiens (Human)
GeneGPR132
SynonymG protein-coupled receptor G2A
G2 accumulation protein
GPR132
DiseaseN/A
Length380
Amino acid sequenceMCPMLLKNGYNGNATPVTTTAPWASLGLSAKTCNNVSFEESRIVLVVVYSAVCTLGVPANCLTAWLALLQVLQGNVLAVYLLCLALCELLYTGTLPLWVIYIRNQHRWTLGLLACKVTAYIFFCNIYVSILFLCCISCDRFVAVVYALESRGRRRRRTAILISACIFILVGIVHYPVFQTEDKETCFDMLQMDSRIAGYYYARFTVGFAIPLSIIAFTNHRIFRSIKQSMGLSAAQKAKVKHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGDRNAMCGLEERLYTASVVFLCLSTVNGVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTDVTRLTHSRDTEELQSPVALADHYTFSRPVHPPGSPCPAKRLIEESC
UniProtQ9UNW8
Protein Data BankN/A
GPCR-HGmod modelQ9UNW8
3D structure modelThis predicted structure model is from GPCR-EXP Q9UNW8.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3085618
IUPHAR128
DrugBankN/A

Ligand

Name9(S)-HODE
Molecular formulaC18H32O3
IUPAC name(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid
Molecular weight296.451
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP5.3
Synonyms9S-hydroxy-10E,12Z-octadecadienoic acid
C14767
IDI1_033955
[S-(E,Z)]-9-hydroxy-10,12-Octadecadienoate
(9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoate
[ Show all ]
Inchi KeyNPDSHTNEKLQQIJ-UINYOVNOSA-N
Inchi IDInChI=1S/C18H32O3/c1-2-3-4-5-6-8-11-14-17(19)15-12-9-7-10-13-16-18(20)21/h6,8,11,14,17,19H,2-5,7,9-10,12-13,15-16H2,1H3,(H,20,21)/b8-6-,14-11+/t17-/m1/s1
PubChem CID5312830
ChEMBLN/A
IUPHAR5567
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC502000.0 nMPMID16236715IUPHAR

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