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GPCR

NameProbable G-protein coupled receptor 32
SpeciesHomo sapiens (Human)
GeneGPR32
SynonymGPR32
resolvin D1 receptor
RvD1
RVDR1
DiseaseN/A
Length356
Amino acid sequenceMNGVSEGTRGCSDRQPGVLTRDRSCSRKMNSSGCLSEEVGSLRPLTVVILSASIVVGVLGNGLVLWMTVFRMARTVSTVCFFHLALADFMLSLSLPIAMYYIVSRQWLLGEWACKLYITFVFLSYFASNCLLVFISVDRCISVLYPVWALNHRTVQRASWLAFGVWLLAAALCSAHLKFRTTRKWNGCTHCYLAFNSDNETAQIWIEGVVEGHIIGTIGHFLLGFLGPLAIIGTCAHLIRAKLLREGWVHANRPKRLLLVLVSAFFIFWSPFNVVLLVHLWRRVMLKEIYHPRMLLILQASFALGCVNSSLNPFLYVFVGRDFQEKFFQSLTSALARAFGEEEFLSSCPRGNAPRE
UniProtO75388
Protein Data BankN/A
GPCR-HGmod modelO75388
3D structure modelThis predicted structure model is from GPCR-EXP O75388.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR99
DrugBankN/A

Ligand

Name[3H]resolvin D1
Molecular formulaC22H32O5
IUPAC name(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
Molecular weight376.493
Hydrogen bond acceptor5
Hydrogen bond donor4
XlogP3.1
SynonymsGTPL3934
(4Z,7S,8S,9E,11E,13Z,15E,17S,19Z)-7,8,17-trihydroxydocosa-4,9,11,13,15,19-hexaenoic acid
RvD1
D05SZG
GTPL4356
[ Show all ]
Inchi KeyOIWTWACQMDFHJG-LDOXQWQISA-N
Inchi IDInChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20-,21-/m0/s1
PubChem CID73755062
ChEMBLN/A
IUPHAR3934, 4356
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC500.0088 nMPMID20080636IUPHAR
Kd0.2 nMPMID20080636IUPHAR

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