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Name | Lysophosphatidic acid receptor 3 |
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Species | Mus musculus (Mouse) |
Gene | Lpar3 |
Synonym | Edg7 endothelial differentiation gene 7, lysophosphatidic acid G-protein-coupled receptor 7 LPA receptor 3 LPA-3 LPA3 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 354 |
Amino acid sequence | MNECHYDKRMDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDTSLTASLANLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVAVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCALQDSNTERRPSRNPSTIHSRSETGSQYLEDSISQGPVCNKNGS |
UniProt | Q9EQ31 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | N/A |
IUPHAR | 274 |
DrugBank | N/A |
Name | D0SH0M |
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Molecular formula | C16H11NO5 |
IUPAC name | 5-(4-methylphenoxy)-1,3-dioxoisoindole-2-carboxylic acid |
Molecular weight | 297.266 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 3.2 |
Synonyms | compound 12 [PMID: 19800804] 5-(4-methylphenoxy)-1,3-dioxoisoindole-2-carboxylic acid GTPL6989 |
Inchi Key | QSPCKQSNISDWOH-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C16H11NO5/c1-9-2-4-10(5-3-9)22-11-6-7-12-13(8-11)15(19)17(14(12)18)16(20)21/h2-8H,1H3,(H,20,21) |
PubChem CID | 73755253 |
ChEMBL | N/A |
IUPHAR | 6989 |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2992.0 nM | PMID19800804 | IUPHAR |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218