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GPCR

NameBeta-3 adrenergic receptor
SpeciesMus musculus (Mouse)
GeneAdrb3
Synonymbeta3-adrenoceptor
beta3-adrenergic receptor
beta-3 adrenoreceptor
Beta-3 adrenoceptor
ADRB
[ Show all ]
DiseaseN/A for non-human GPCRs
Length400
Amino acid sequenceMAPWPHRNGSLALWSDAPTLDPSAANTSGLPGVPWAAALAGALLALATVGGNLLVIIAIARTPRLQTITNVFVTSLAAADLVVGLLVMPPGATLALTGHWPLGETGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGTLVTKRRARAAVVLVWIVSAAVSFAPIMSQWWRVGADAEAQECHSNPRCCSFASNMPYALLSSSVSFYLPLLVMLFVYARVFVVAKRQRHLLRRELGRFSPEESPPSPSRSPSPATGGTPAAPDGVPPCGRRPARLLPLREHRALRTLGLIMGIFSLCWLPFFLANVLRALAGPSLVPSGVFIALNWLGYANSAFNPVIYCRSPDFRDAFRRLLCSYGGRGPEEPRAVTFPASPVEARQSPPLNRFDGYEGARPFPT
UniProtP25962
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4030
IUPHAR30
DrugBankN/A

Ligand

Namenorepinephrine
Molecular formulaC8H11NO3
IUPAC name4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol
Molecular weight169.18
Hydrogen bond acceptor4
Hydrogen bond donor4
XlogP-1.2
Synonyms4786-EP2287165A2
Spectrum2_001064
I01-15661
4786-EP2308864A1
to_000024
[ Show all ]
Inchi KeySFLSHLFXELFNJZ-QMMMGPOBSA-N
Inchi IDInChI=1S/C8H11NO3/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3,8,10-12H,4,9H2/t8-/m0/s1
PubChem CID439260
ChEMBLCHEMBL1437
IUPHAR505
BindingDB50029051
DrugBankDB00368

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki158489.0 nMPMID14744619IUPHAR

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